PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34604061-2	2021	The multi-kinase inhibitor axitinib interacted with multiple HDAC inhibitors to kill sarcoma cells.	Axitinib	27-35	histone deacetylase 9	Homo sapiens	61-65	
34604061-3	2021	Axitinib and HDAC inhibitors interacted in a greater than additive fashion to inactivate AKT, mTORC1 and mTORC2, and to increase Raptor S722/S792 phosphorylation.	Axitinib	0-8	AKT serine/threonine kinase 1	Homo sapiens	89-92	
34604061-3	2021	Axitinib and HDAC inhibitors interacted in a greater than additive fashion to inactivate AKT, mTORC1 and mTORC2, and to increase Raptor S722/S792 phosphorylation.	Axitinib	0-8	CREB regulated transcription coactivator 1	Mus musculus	94-100	
34604061-3	2021	Axitinib and HDAC inhibitors interacted in a greater than additive fashion to inactivate AKT, mTORC1 and mTORC2, and to increase Raptor S722/S792 phosphorylation.	Axitinib	0-8	CREB regulated transcription coactivator 2	Mus musculus	105-111	
34604061-3	2021	Axitinib and HDAC inhibitors interacted in a greater than additive fashion to inactivate AKT, mTORC1 and mTORC2, and to increase Raptor S722/S792 phosphorylation.	Axitinib	0-8	regulatory associated protein of MTOR complex 1	Homo sapiens	129-135	
34604061-6	2021	ULK1 S757 is a recognized site for mTORC1 and knock down of either ATM or AMPKalpha reduced the drug-induced dephosphorylation of this site.	ampkalpha	74-83	unc-51 like autophagy activating kinase 1	Homo sapiens	0-4	
34604061-6	2021	ULK1 S757 is a recognized site for mTORC1 and knock down of either ATM or AMPKalpha reduced the drug-induced dephosphorylation of this site.	ampkalpha	74-83	CREB regulated transcription coactivator 1	Mus musculus	35-41	
34604061-7	2021	Combined exposure of cells to axitinib and an HDAC inhibitor significantly reduced the expression of HDAC1, HDAC2, HDAC3, HDAC4, HDAC6 and HDAC7.	Axitinib	30-38	histone deacetylase 9	Homo sapiens	46-50	
34604061-7	2021	Combined exposure of cells to axitinib and an HDAC inhibitor significantly reduced the expression of HDAC1, HDAC2, HDAC3, HDAC4, HDAC6 and HDAC7.	Axitinib	30-38	histone deacetylase 1	Homo sapiens	101-106	
34604061-7	2021	Combined exposure of cells to axitinib and an HDAC inhibitor significantly reduced the expression of HDAC1, HDAC2, HDAC3, HDAC4, HDAC6 and HDAC7.	Axitinib	30-38	histone deacetylase 2	Homo sapiens	108-113	
34604061-7	2021	Combined exposure of cells to axitinib and an HDAC inhibitor significantly reduced the expression of HDAC1, HDAC2, HDAC3, HDAC4, HDAC6 and HDAC7.	Axitinib	30-38	histone deacetylase 3	Homo sapiens	115-120	
34604061-7	2021	Combined exposure of cells to axitinib and an HDAC inhibitor significantly reduced the expression of HDAC1, HDAC2, HDAC3, HDAC4, HDAC6 and HDAC7.	Axitinib	30-38	histone deacetylase 4	Homo sapiens	122-127	
34604061-7	2021	Combined exposure of cells to axitinib and an HDAC inhibitor significantly reduced the expression of HDAC1, HDAC2, HDAC3, HDAC4, HDAC6 and HDAC7.	Axitinib	30-38	histone deacetylase 6	Homo sapiens	129-134	
34604061-7	2021	Combined exposure of cells to axitinib and an HDAC inhibitor significantly reduced the expression of HDAC1, HDAC2, HDAC3, HDAC4, HDAC6 and HDAC7.	Axitinib	30-38	histone deacetylase 7	Homo sapiens	139-144	
34604061-10	2021	Axitinib combined with HDAC inhibitors enhanced expression of Class I MHCA and reduced expression of PD-L1 which was recapitulated via knock down studies, particularly of HDACs 1 and 3.	Axitinib	0-8	CD274 molecule	Homo sapiens	101-106	
34604061-11	2021	In vivo, axitinib and the HDAC inhibitor entinostat interacted to significantly reduce tumor growth.	Axitinib	9-17	histone deacetylase 9	Homo sapiens	26-30	
34604061-11	2021	In vivo, axitinib and the HDAC inhibitor entinostat interacted to significantly reduce tumor growth.	entinostat	41-51	histone deacetylase 9	Homo sapiens	26-30