PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34601428-5 2021 We further demonstrated that endothelial peroxynitrite (ONOO-) formation in the Arc induced nitrosative stress following cisplatin treatment via a previously uncharacterized pathway involving neuronal caspase-1 activation. Cisplatin 121-130 caspase 1 Mus musculus 201-210 34601428-8 2021 Taken together, these results suggest, for the first time, that targeting the overproduction of endothelial ONOO- can regulate cisplatin-induced neurotoxicity through neuronal caspase-1, and thereby serve as a potential therapeutic approach to alleviate chemotherapy-induced anorexia and weight loss. Cisplatin 127-136 caspase 1 Mus musculus 176-185