PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34570508-0 2021 Discovery of 5-{4-((7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl)piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs. AZD5305 123-130 poly(ADP-ribose) polymerase 1 Homo sapiens 135-140 34570508-0 2021 Discovery of 5-{4-((7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl)piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs. AZD5305 123-130 poly(ADP-ribose) polymerase 1 Homo sapiens 179-184 34570508-0 2021 Discovery of 5-{4-((7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl)piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs. AZD5305 123-130 poly(ADP-ribose) polymerase 1 Homo sapiens 206-211 34570508-5 2021 Herein, we describe the structure- and property-based design of 25 (AZD5305), a potent and selective PARP1 inhibitor and PARP1-DNA trapper with excellent in vivo efficacy in a BRCA mutant HBCx-17 PDX model. AZD5305 68-75 poly(ADP-ribose) polymerase 1 Homo sapiens 101-106 34570508-5 2021 Herein, we describe the structure- and property-based design of 25 (AZD5305), a potent and selective PARP1 inhibitor and PARP1-DNA trapper with excellent in vivo efficacy in a BRCA mutant HBCx-17 PDX model. AZD5305 68-75 poly(ADP-ribose) polymerase 1 Homo sapiens 121-126