PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34564613-0 2021 Effect of (-)-Epigallocatechin Gallate on Activation of JAK/STAT Signaling Pathway by Staphylococcal Enterotoxin A. Staphylococcal enterotoxin A (SEA), which is a superantigen toxin protein, binds to cytokine receptor gp130. epigallocatechin gallate 10-38 signal transducer and activator of transcription 3 Mus musculus 60-64 34564613-0 2021 Effect of (-)-Epigallocatechin Gallate on Activation of JAK/STAT Signaling Pathway by Staphylococcal Enterotoxin A. Staphylococcal enterotoxin A (SEA), which is a superantigen toxin protein, binds to cytokine receptor gp130. epigallocatechin gallate 10-38 interleukin 6 signal transducer Mus musculus 218-223 34564613-4 2021 SEA-induced IFN-gamma and SOCS1 expression were decreased by treatment with (-)-epigallocatechin gallate (EGCG). epigallocatechin gallate 76-104 interferon gamma Mus musculus 12-21 34564613-4 2021 SEA-induced IFN-gamma and SOCS1 expression were decreased by treatment with (-)-epigallocatechin gallate (EGCG). epigallocatechin gallate 76-104 suppressor of cytokine signaling 1 Mus musculus 26-31 34564613-4 2021 SEA-induced IFN-gamma and SOCS1 expression were decreased by treatment with (-)-epigallocatechin gallate (EGCG). epigallocatechin gallate 106-110 interferon gamma Mus musculus 12-21 34564613-4 2021 SEA-induced IFN-gamma and SOCS1 expression were decreased by treatment with (-)-epigallocatechin gallate (EGCG). epigallocatechin gallate 106-110 suppressor of cytokine signaling 1 Mus musculus 26-31 34564613-6 2021 Although (-)-3""-Me-EGCG did not inhibit SEA-induced phosphorylated STAT3, EGCG and (-)-4""-Me-EGCG significantly inhibited SEA-induced phosphorylated STAT3. (-)-3""-me-egcg 9-24 signal transducer and activator of transcription 3 Mus musculus 151-156 34564613-6 2021 Although (-)-3""-Me-EGCG did not inhibit SEA-induced phosphorylated STAT3, EGCG and (-)-4""-Me-EGCG significantly inhibited SEA-induced phosphorylated STAT3. epigallocatechin gallate 75-79 signal transducer and activator of transcription 3 Mus musculus 151-156 34564613-6 2021 Although (-)-3""-Me-EGCG did not inhibit SEA-induced phosphorylated STAT3, EGCG and (-)-4""-Me-EGCG significantly inhibited SEA-induced phosphorylated STAT3. (-)-4""-me-egcg 84-99 signal transducer and activator of transcription 3 Mus musculus 151-156 34564613-7 2021 It was thought that the hydroxyl group at position 3 of the galloyl group in the EGCG was responsible for binding to SEA and suppressing SEA-induced phosphorylation of STAT3. epigallocatechin gallate 81-85 signal transducer and activator of transcription 3 Mus musculus 168-173 34564613-8 2021 Through protein thermal shift assay in vitro, the binding of the gp130 receptor to SEA and the phosphorylation of STAT3 were inhibited by the interaction between EGCG and SEA. epigallocatechin gallate 162-166 interleukin 6 signal transducer Mus musculus 65-70 34564613-8 2021 Through protein thermal shift assay in vitro, the binding of the gp130 receptor to SEA and the phosphorylation of STAT3 were inhibited by the interaction between EGCG and SEA. epigallocatechin gallate 162-166 signal transducer and activator of transcription 3 Mus musculus 114-119 34564613-9 2021 As far as we know, this is the first report to document that EGCG inhibits the binding of the gp130 receptor to SEA and the associated phosphorylation of STAT3. epigallocatechin gallate 61-65 interleukin 6 signal transducer Mus musculus 94-99 34564613-9 2021 As far as we know, this is the first report to document that EGCG inhibits the binding of the gp130 receptor to SEA and the associated phosphorylation of STAT3. epigallocatechin gallate 61-65 signal transducer and activator of transcription 3 Mus musculus 154-159