PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34544906-0	2021	A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-alpha, -beta/delta, -gamma, and RXR antagonists and by norbixin.	N-retinylidene-N-retinylethanolamine	0-3	peroxisome proliferator activated receptor alpha	Homo sapiens	81-112	
34544906-0	2021	A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-alpha, -beta/delta, -gamma, and RXR antagonists and by norbixin.	N-retinylidene-N-retinylethanolamine	0-3	retinoid X receptor alpha	Homo sapiens	118-121	
34544906-5	2021	Norbixin inhibits PPAR and RXR transactivation induced by A2E.	norbixin	0-8	peroxisome proliferator activated receptor alpha	Homo sapiens	18-22	
34544906-5	2021	Norbixin inhibits PPAR and RXR transactivation induced by A2E.	norbixin	0-8	retinoid X receptor alpha	Homo sapiens	27-30	
34544906-6	2021	Moreover, norbixin reduces protein kinase B (AKT) phosphorylation, NF-kappaB and AP-1 transactivation and mRNA expression of the inflammatory interleukins (IL) -6 and -8 and of vascular endothelial growth factor (VEGF) enhanced by A2E.	norbixin	10-18	protein tyrosine kinase 2 beta	Homo sapiens	27-43	
34544906-6	2021	Moreover, norbixin reduces protein kinase B (AKT) phosphorylation, NF-kappaB and AP-1 transactivation and mRNA expression of the inflammatory interleukins (IL) -6 and -8 and of vascular endothelial growth factor (VEGF) enhanced by A2E.	norbixin	10-18	AKT serine/threonine kinase 1	Homo sapiens	45-48	
34544906-6	2021	Moreover, norbixin reduces protein kinase B (AKT) phosphorylation, NF-kappaB and AP-1 transactivation and mRNA expression of the inflammatory interleukins (IL) -6 and -8 and of vascular endothelial growth factor (VEGF) enhanced by A2E.	norbixin	10-18	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	81-85	
34544906-6	2021	Moreover, norbixin reduces protein kinase B (AKT) phosphorylation, NF-kappaB and AP-1 transactivation and mRNA expression of the inflammatory interleukins (IL) -6 and -8 and of vascular endothelial growth factor (VEGF) enhanced by A2E.	norbixin	10-18	interleukin 6	Homo sapiens	142-169	
34544906-6	2021	Moreover, norbixin reduces protein kinase B (AKT) phosphorylation, NF-kappaB and AP-1 transactivation and mRNA expression of the inflammatory interleukins (IL) -6 and -8 and of vascular endothelial growth factor (VEGF) enhanced by A2E.	norbixin	10-18	vascular endothelial growth factor A	Homo sapiens	177-211	
34544906-6	2021	Moreover, norbixin reduces protein kinase B (AKT) phosphorylation, NF-kappaB and AP-1 transactivation and mRNA expression of the inflammatory interleukins (IL) -6 and -8 and of vascular endothelial growth factor (VEGF) enhanced by A2E.	norbixin	10-18	vascular endothelial growth factor A	Homo sapiens	213-217	
34544906-7	2021	By contrast, norbixin increases matrix metalloproteinase 9 (MMP9) and C-C motif chemokine ligand 2 (CCL2) mRNA expression in response to A2E.	norbixin	13-21	matrix metallopeptidase 9	Homo sapiens	32-58	
34544906-7	2021	By contrast, norbixin increases matrix metalloproteinase 9 (MMP9) and C-C motif chemokine ligand 2 (CCL2) mRNA expression in response to A2E.	norbixin	13-21	matrix metallopeptidase 9	Homo sapiens	60-64	
34544906-7	2021	By contrast, norbixin increases matrix metalloproteinase 9 (MMP9) and C-C motif chemokine ligand 2 (CCL2) mRNA expression in response to A2E.	norbixin	13-21	C-C motif chemokine ligand 2	Homo sapiens	70-98	
34544906-7	2021	By contrast, norbixin increases matrix metalloproteinase 9 (MMP9) and C-C motif chemokine ligand 2 (CCL2) mRNA expression in response to A2E.	norbixin	13-21	C-C motif chemokine ligand 2	Homo sapiens	100-104	
34544906-9	2021	In addition, a cocktail of all three PPARs antagonists and also HX531, an antagonist of RXR reproduce norbixin effects on inflammation.	norbixin	102-110	retinoid X receptor alpha	Homo sapiens	88-91