PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34482362-5 2021 We found that pharmacologic inhibition of neddylation using a small-molecule inhibitor, MLN4924/Pevonedistat, increases the expression of the NK cell-activating receptor NKG2D ligands MICA and MICB on the plasma membrane of different MM cell lines and patient-derived PCs, leading to enhanced NK cell degranulation. pevonedistat 88-95 MHC class I polypeptide-related sequence B Homo sapiens 193-197 34482362-5 2021 We found that pharmacologic inhibition of neddylation using a small-molecule inhibitor, MLN4924/Pevonedistat, increases the expression of the NK cell-activating receptor NKG2D ligands MICA and MICB on the plasma membrane of different MM cell lines and patient-derived PCs, leading to enhanced NK cell degranulation. pevonedistat 96-108 MHC class I polypeptide-related sequence B Homo sapiens 193-197 34482362-7 2021 Differently, MLN4924/Pevonedistat induced accumulation of MICB on the plasma membrane with no change of its mRNA levels, indicating a post-translational regulatory mechanism. pevonedistat 13-20 MHC class I polypeptide-related sequence B Homo sapiens 58-62 34482362-7 2021 Differently, MLN4924/Pevonedistat induced accumulation of MICB on the plasma membrane with no change of its mRNA levels, indicating a post-translational regulatory mechanism. pevonedistat 21-33 MHC class I polypeptide-related sequence B Homo sapiens 58-62