PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34454514-2 2021 Virion assembly and maturation are facilitated by the cellular polyanion inositol hexaphosphate (IP6), which is proposed to stabilize both the immature Gag lattice and the mature capsid lattice by binding to rings of primary amines at the center of Gag or capsid protein (CA) hexamers. Phytic Acid 97-100 Pr55(Gag) Human immunodeficiency virus 1 152-155 34454514-2 2021 Virion assembly and maturation are facilitated by the cellular polyanion inositol hexaphosphate (IP6), which is proposed to stabilize both the immature Gag lattice and the mature capsid lattice by binding to rings of primary amines at the center of Gag or capsid protein (CA) hexamers. Phytic Acid 97-100 Pr55(Gag) Human immunodeficiency virus 1 249-252 34454514-5 2021 RESULTS: We found a mutation, a threonine to isoleucine substitution at position 371 (T371I) in Gag, that restored replication competence to an IP6-binding-deficient HIV-1 mutant. Phytic Acid 144-147 Pr55(Gag) Human immunodeficiency virus 1 96-99 34454514-9 2021 CONCLUSIONS: Overall these results suggest that IP6-Gag and Gag-Gag contacts are finely tuned to generate a Gag lattice of optimal stability, and that under certain conditions BVM can rescue IP6 deficiency. Phytic Acid 48-51 Pr55(Gag) Human immunodeficiency virus 1 52-55 34454514-9 2021 CONCLUSIONS: Overall these results suggest that IP6-Gag and Gag-Gag contacts are finely tuned to generate a Gag lattice of optimal stability, and that under certain conditions BVM can rescue IP6 deficiency. Phytic Acid 48-51 Pr55(Gag) Human immunodeficiency virus 1 108-111