PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34438042-2 2021 Here we demonstrate that the hydrophobic bile acid, deoxycholic acid (DCA), stimulated the production of IL-6 and IL-8 mRNA and protein in Het-1A, a model of normal oesophageal cells. Deoxycholic Acid 52-68 interleukin 6 Homo sapiens 105-109 34438042-2 2021 Here we demonstrate that the hydrophobic bile acid, deoxycholic acid (DCA), stimulated the production of IL-6 and IL-8 mRNA and protein in Het-1A, a model of normal oesophageal cells. Deoxycholic Acid 70-73 interleukin 6 Homo sapiens 105-109 34438042-3 2021 DCA-induced production of IL-6 and IL-8 was attenuated by pharmacologic inhibition of the Protein Kinase C (PKC), MAP kinase, tyrosine kinase pathways, by the cholesterol sequestering agent, methyl-beta-cyclodextrin (MCD) and by the hydrophilic bile acid, ursodeoxycholic acid (UDCA). Deoxycholic Acid 0-3 interleukin 6 Homo sapiens 26-30 34438042-4 2021 The cholesterol-interacting agent, nystatin, which binds cholesterol without removing it from the membrane, synergized with DCA to induce IL-6 and IL-8. Deoxycholic Acid 124-127 interleukin 6 Homo sapiens 138-142 34438042-8 2021 Taken together, these results demonstrate that DCA stimulates IL-6 and IL-8 production in oesophageal cells via lipid raft-associated signaling. Deoxycholic Acid 47-50 interleukin 6 Homo sapiens 62-66