PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34323243-0 2021 Curcumin enhances the membrane trafficking of the sodium iodide symporter and augments radioiodine uptake in dedifferentiated thyroid cancer cells via suppression of the PI3K-AKT signaling pathway. Curcumin 0-8 AKT serine/threonine kinase 1 Homo sapiens 175-178 34323243-7 2021 Additionally, AKT knockdown phenocopied the restoration of thyroid-specific gene expression; however, ectopic expressed AKT inhibited curcumin-induced up-regulation of NIS protein, demonstrating that curcumin might improve radioiodine sensitivity via the inhibition of the PI3K-AKT-mTOR signaling pathway. Curcumin 134-142 AKT serine/threonine kinase 1 Homo sapiens 120-123 34323243-7 2021 Additionally, AKT knockdown phenocopied the restoration of thyroid-specific gene expression; however, ectopic expressed AKT inhibited curcumin-induced up-regulation of NIS protein, demonstrating that curcumin might improve radioiodine sensitivity via the inhibition of the PI3K-AKT-mTOR signaling pathway. Curcumin 200-208 AKT serine/threonine kinase 1 Homo sapiens 14-17 34323243-7 2021 Additionally, AKT knockdown phenocopied the restoration of thyroid-specific gene expression; however, ectopic expressed AKT inhibited curcumin-induced up-regulation of NIS protein, demonstrating that curcumin might improve radioiodine sensitivity via the inhibition of the PI3K-AKT-mTOR signaling pathway. Curcumin 200-208 AKT serine/threonine kinase 1 Homo sapiens 120-123 34323243-7 2021 Additionally, AKT knockdown phenocopied the restoration of thyroid-specific gene expression; however, ectopic expressed AKT inhibited curcumin-induced up-regulation of NIS protein, demonstrating that curcumin might improve radioiodine sensitivity via the inhibition of the PI3K-AKT-mTOR signaling pathway. Curcumin 200-208 AKT serine/threonine kinase 1 Homo sapiens 278-281