PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34308845-0 2021 (Macrophage migration inhibitory factor meditates MPP+/MPTP-induced NLRP3 inflammasome activation in microglia cells). mangion-purified polysaccharide (Candida albicans) 50-54 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 1-39 34308845-0 2021 (Macrophage migration inhibitory factor meditates MPP+/MPTP-induced NLRP3 inflammasome activation in microglia cells). mangion-purified polysaccharide (Candida albicans) 50-54 NLR family, pyrin domain containing 3 Mus musculus 68-73 34308845-0 2021 (Macrophage migration inhibitory factor meditates MPP+/MPTP-induced NLRP3 inflammasome activation in microglia cells). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 55-59 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 1-39 34308845-0 2021 (Macrophage migration inhibitory factor meditates MPP+/MPTP-induced NLRP3 inflammasome activation in microglia cells). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 55-59 NLR family, pyrin domain containing 3 Mus musculus 68-73 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. MPP+ iodide 132-166 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 40-78 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. MPP+ iodide 132-166 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 80-83 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. MPP+ iodide 132-166 membrane protein, palmitoylated Mus musculus 168-176 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. MPP+ iodide 132-166 NLR family, pyrin domain containing 3 Mus musculus 252-279 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. MPP+ iodide 132-166 NLR family, pyrin domain containing 3 Mus musculus 281-286 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. -methyl- 176-184 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 40-78 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. -methyl- 176-184 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 80-83 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. -methyl- 176-184 NLR family, pyrin domain containing 3 Mus musculus 252-279 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. -methyl- 176-184 NLR family, pyrin domain containing 3 Mus musculus 281-286 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. -phenyl-1, 2, 3, 6-tetrahydropyridine 185-222 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 40-78 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. -phenyl-1, 2, 3, 6-tetrahydropyridine 185-222 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 80-83 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. -phenyl-1, 2, 3, 6-tetrahydropyridine 185-222 membrane protein, palmitoylated Mus musculus 168-176 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. -phenyl-1, 2, 3, 6-tetrahydropyridine 185-222 NLR family, pyrin domain containing 3 Mus musculus 252-279 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. -phenyl-1, 2, 3, 6-tetrahydropyridine 185-222 NLR family, pyrin domain containing 3 Mus musculus 281-286 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 224-228 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 40-78 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 224-228 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 80-83 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 224-228 membrane protein, palmitoylated Mus musculus 168-176 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 224-228 NLR family, pyrin domain containing 3 Mus musculus 252-279 34308845-1 2021 OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 224-228 NLR family, pyrin domain containing 3 Mus musculus 281-286 34308845-5 2021 The effect of stereotactic injection of an adeno-associated virus (AAV) carrying MIF shRNA on behaviors was assessed in a C57BL/6 mouse model of Parkinson disease (PD) induced by intraperitoneal MPTP injection. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 195-199 macrophage migration inhibitory factor Homo sapiens 81-84 34308845-7 2021 RESULTS: MPP+ significantly increased NLRP3 and MIF expressions in Bv-2 cells (P < 0.05). mangion-purified polysaccharide (Candida albicans) 9-13 NLR family, pyrin domain containing 3 Mus musculus 38-43 34308845-7 2021 RESULTS: MPP+ significantly increased NLRP3 and MIF expressions in Bv-2 cells (P < 0.05). mangion-purified polysaccharide (Candida albicans) 9-13 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 48-51 34308845-11 2021 Compared with those in MPTP group, the mice receiving injections of AAV-MIF-shRNA had higher scores in pole test and open field test with lower scores in traction test, and showed increased TH-positive neurons, decreased Iba-1 microglia cell activation, reduced expressions of MIF and NLRP3, and increased expression of TH in he substantia nigra (all P < 0.05). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 23-27 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 72-75 34308845-11 2021 Compared with those in MPTP group, the mice receiving injections of AAV-MIF-shRNA had higher scores in pole test and open field test with lower scores in traction test, and showed increased TH-positive neurons, decreased Iba-1 microglia cell activation, reduced expressions of MIF and NLRP3, and increased expression of TH in he substantia nigra (all P < 0.05). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 23-27 induction of brown adipocytes 1 Mus musculus 221-226 34308845-11 2021 Compared with those in MPTP group, the mice receiving injections of AAV-MIF-shRNA had higher scores in pole test and open field test with lower scores in traction test, and showed increased TH-positive neurons, decreased Iba-1 microglia cell activation, reduced expressions of MIF and NLRP3, and increased expression of TH in he substantia nigra (all P < 0.05). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 23-27 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 277-280 34308845-11 2021 Compared with those in MPTP group, the mice receiving injections of AAV-MIF-shRNA had higher scores in pole test and open field test with lower scores in traction test, and showed increased TH-positive neurons, decreased Iba-1 microglia cell activation, reduced expressions of MIF and NLRP3, and increased expression of TH in he substantia nigra (all P < 0.05). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 23-27 NLR family, pyrin domain containing 3 Mus musculus 285-290 34308845-11 2021 Compared with those in MPTP group, the mice receiving injections of AAV-MIF-shRNA had higher scores in pole test and open field test with lower scores in traction test, and showed increased TH-positive neurons, decreased Iba-1 microglia cell activation, reduced expressions of MIF and NLRP3, and increased expression of TH in he substantia nigra (all P < 0.05). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 23-27 tyrosine hydroxylase Mus musculus 320-322 34308845-12 2021 CONCLUSION: Inhibition of MIF can reduce the expression of NLRP3 inflammasomes and inflammatory factor caused by MPP+ in microglia cells to relieve the damage of dopaminergic neurons and alleviate microglia cell activation, thus offering protection against neuroinflammation in Parkinson"s disease. mangion-purified polysaccharide (Candida albicans) 113-117 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 26-29 34308845-12 2021 CONCLUSION: Inhibition of MIF can reduce the expression of NLRP3 inflammasomes and inflammatory factor caused by MPP+ in microglia cells to relieve the damage of dopaminergic neurons and alleviate microglia cell activation, thus offering protection against neuroinflammation in Parkinson"s disease. mangion-purified polysaccharide (Candida albicans) 113-117 NLR family, pyrin domain containing 3 Mus musculus 59-64