PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34224824-5	2021	Isotretinoin is associated with pro-apoptotic signaling in sebaceous glands through upregulated expression of p53, forkhead box O transcription factors (FOXO1, FOXO3), and tumor necrosis factor-related apoptosis inducing ligand (TRAIL).	Isotretinoin	0-12	tumor protein p53	Homo sapiens	110-113	
34224824-6	2021	Two literature searches including clinical and experimental studies respectively support the hypothesis that isotretinoin s toxicological mode of action on the pituitary-ovarian axis might be caused by over-expressed p53/FOXO1 signaling resulting in gonadotropin suppression and granulosa cell apoptosis.	Isotretinoin	109-121	tumor protein p53	Homo sapiens	217-220