PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34224367-1 2021 Inhibition of mTORC1 signaling has been shown to diminish growth of meningiomas and schwannomas in preclinical studies, and clinical data suggest that everolimus, an orally administered mTORC1 inhibitor, may slow tumor progression in a subset of NF2 patients with vestibular schwannoma (VS). Everolimus 151-161 CREB regulated transcription coactivator 1 Mus musculus 186-192 34224367-11 2021 These data may explain the limited anti-tumor effect of everolimus observed in clinical studies for NF2 patients and will inform the design of future pre-clinical and clinical studies targeting mTORC1 in meningiomas and schwannomas. Everolimus 56-66 CREB regulated transcription coactivator 1 Mus musculus 194-200