PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34115948-3 2021 The opioid, morphine, initiates a Toll-like receptor 4 (TLR4) signaling cascade that drives the activation of NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome proteins, resulting in cytokine production and effectively creating a positive feedback loop for continuous TLR4 activation. Morphine 12-20 NLR family pyrin domain containing 3 Homo sapiens 110-159 34115948-3 2021 The opioid, morphine, initiates a Toll-like receptor 4 (TLR4) signaling cascade that drives the activation of NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome proteins, resulting in cytokine production and effectively creating a positive feedback loop for continuous TLR4 activation. Morphine 12-20 NLR family pyrin domain containing 3 Homo sapiens 161-166