PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34114395-0	2021	Celastrol induces caspase-dependent apoptosis of hepatocellular carcinoma cells by suppression of mammalian target of rapamycin.	celastrol	0-9	caspase 8	Homo sapiens	18-25	
34114395-8	2021	Western blot assays indicated that celastrol up-regulated cleaved-caspase-3, cleaved-caspase-8, cleaved-caspase-9, and cleaved-PARP by inhibiting the phosphorylation of mTOR in HepG2 cells.	celastrol	35-44	caspase 8	Homo sapiens	85-94	
34114395-10	2021	Celastrol also induced caspase-dependent apoptosis (up-regulation of cleaved-caspase- 3, -8, -9, and cleaved-PARP) and inhibited the activation of mTOR in vivo.	celastrol	0-9	caspase 8	Homo sapiens	23-30	
34114395-11	2021	CONCLUSION: Celastrol induces caspase-dependent apoptosis in HCC cells by inhibiting the activation of mTOR.	celastrol	12-21	caspase 8	Homo sapiens	30-37