PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34090859-10 2021 Treatment with daidzein at dose 100 mg/kg significantly improved the SBP, DBP, and MAP. daidzein 15-23 spermine binding protein Rattus norvegicus 69-72 34090859-10 2021 Treatment with daidzein at dose 100 mg/kg significantly improved the SBP, DBP, and MAP. daidzein 15-23 D-box binding PAR bZIP transcription factor Rattus norvegicus 74-77 34090859-11 2021 Daidzein treatment prevented the loss of cardiac marker enzyme from heart tissue and also increased the level of AMPK and SIRT1 in plasma. daidzein 0-8 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 113-117 34090859-11 2021 Daidzein treatment prevented the loss of cardiac marker enzyme from heart tissue and also increased the level of AMPK and SIRT1 in plasma. daidzein 0-8 sirtuin 1 Rattus norvegicus 122-127 34090859-12 2021 Protein expression of NOX-4 and RAC-1 was also found to be reduced daidzein treated animals. daidzein 67-75 NADPH oxidase 4 Rattus norvegicus 22-27 34090859-12 2021 Protein expression of NOX-4 and RAC-1 was also found to be reduced daidzein treated animals. daidzein 67-75 Rac family small GTPase 1 Rattus norvegicus 32-37 34090859-14 2021 SIGNIFICANCE: From all the results, it can be concluded that daidzein mitigates the progression of diabetic cardiomyopathy by inhibiting NOX-4 induced oxidative stress in cardiac tissue. daidzein 61-69 NADPH oxidase 4 Rattus norvegicus 137-142