PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33871064-0 2021 Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD. NAD 160-163 CD38 antigen Mus musculus 14-18 33871064-4 2021 Our previous study demonstrated that deletion of CD38, which consumes NAD+ , suppressed cuprizone-induced demyelination, neuroinflammation and glial activation. NAD 70-74 CD38 antigen Mus musculus 49-53 33871064-5 2021 However, it is still unknown whether CD38 directly affects neuroinflammation through regulating brain NAD+ level. NAD 102-106 CD38 antigen Mus musculus 37-41 33871064-12 2021 These results suggest that CD38-mediated neuroinflammation is linked to NAD+ consumption and that boosting NAD+ by CD38 inhibition and NR supplementation directly suppress neuroinflammation in the brain. NAD 72-76 CD38 antigen Mus musculus 27-31 33871064-12 2021 These results suggest that CD38-mediated neuroinflammation is linked to NAD+ consumption and that boosting NAD+ by CD38 inhibition and NR supplementation directly suppress neuroinflammation in the brain. NAD 107-111 CD38 antigen Mus musculus 115-119