PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33824698-0	2021	Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene.	Raloxifene Hydrochloride	144-154	interleukin 6	Mus musculus	119-123	
33824698-0	2021	Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene.	Raloxifene Hydrochloride	144-154	signal transducer and activator of transcription 3	Mus musculus	124-129	
33824698-5	2021	Echocardiographic and histological results showed that cardiac hypertrophy, fibrosis, and left ventricular dysfunction were manifested in mice after TAC treatment of eight weeks, with aggravation of macrophage infiltration and interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) expression in the myocardium.	tac	149-152	interleukin 6	Mus musculus	227-240	
33824698-5	2021	Echocardiographic and histological results showed that cardiac hypertrophy, fibrosis, and left ventricular dysfunction were manifested in mice after TAC treatment of eight weeks, with aggravation of macrophage infiltration and interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) expression in the myocardium.	tac	149-152	interleukin 6	Mus musculus	242-246	
33824698-5	2021	Echocardiographic and histological results showed that cardiac hypertrophy, fibrosis, and left ventricular dysfunction were manifested in mice after TAC treatment of eight weeks, with aggravation of macrophage infiltration and interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) expression in the myocardium.	tac	149-152	tumor necrosis factor	Mus musculus	252-279	
33824698-5	2021	Echocardiographic and histological results showed that cardiac hypertrophy, fibrosis, and left ventricular dysfunction were manifested in mice after TAC treatment of eight weeks, with aggravation of macrophage infiltration and interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) expression in the myocardium.	tac	149-152	tumor necrosis factor	Mus musculus	281-290	
33824698-6	2021	TAC (four and eight weeks) elevated the phosphorylation of signal transducer and activator of transcription 3 (p-STAT3) and prohibitin2 (PHB2) protein expression.	tac	0-3	signal transducer and activator of transcription 3	Mus musculus	59-109	
33824698-6	2021	TAC (four and eight weeks) elevated the phosphorylation of signal transducer and activator of transcription 3 (p-STAT3) and prohibitin2 (PHB2) protein expression.	tac	0-3	signal transducer and activator of transcription 3	Mus musculus	113-118	
33824698-6	2021	TAC (four and eight weeks) elevated the phosphorylation of signal transducer and activator of transcription 3 (p-STAT3) and prohibitin2 (PHB2) protein expression.	tac	0-3	prohibitin 2	Mus musculus	124-135	
33824698-6	2021	TAC (four and eight weeks) elevated the phosphorylation of signal transducer and activator of transcription 3 (p-STAT3) and prohibitin2 (PHB2) protein expression.	tac	0-3	prohibitin 2	Mus musculus	137-141	
33824698-7	2021	Importantly, IL-6/gp130/STAT3 inhibition by raloxifene alleviated TAC-induced myocardial inflammation, cardiac remodeling, and dysfunction.	Raloxifene Hydrochloride	44-54	interleukin 6	Mus musculus	13-17	
33824698-7	2021	Importantly, IL-6/gp130/STAT3 inhibition by raloxifene alleviated TAC-induced myocardial inflammation, cardiac remodeling, and dysfunction.	Raloxifene Hydrochloride	44-54	interleukin 6 signal transducer	Mus musculus	18-23	
33824698-7	2021	Importantly, IL-6/gp130/STAT3 inhibition by raloxifene alleviated TAC-induced myocardial inflammation, cardiac remodeling, and dysfunction.	Raloxifene Hydrochloride	44-54	signal transducer and activator of transcription 3	Mus musculus	24-29	
33824698-7	2021	Importantly, IL-6/gp130/STAT3 inhibition by raloxifene alleviated TAC-induced myocardial inflammation, cardiac remodeling, and dysfunction.	tac	66-69	interleukin 6	Mus musculus	13-17	
33824698-7	2021	Importantly, IL-6/gp130/STAT3 inhibition by raloxifene alleviated TAC-induced myocardial inflammation, cardiac remodeling, and dysfunction.	tac	66-69	interleukin 6 signal transducer	Mus musculus	18-23	
33824698-7	2021	Importantly, IL-6/gp130/STAT3 inhibition by raloxifene alleviated TAC-induced myocardial inflammation, cardiac remodeling, and dysfunction.	tac	66-69	signal transducer and activator of transcription 3	Mus musculus	24-29	
33824698-9	2021	Sustained IL-6 stimulation increased intracellular reactive oxygen species, repressed mitochondrial membrane potential (MMP), decreased intracellular content of ATP, and led to decreased SOD activity, an increase in iNOS protein expression, and increased protein expression of Pink1, Parkin, and Bnip3 involving in mitophagy, all of which were reversed by raloxifene.	Oxygen	60-66	interleukin 6	Mus musculus	10-14	
33824698-9	2021	Sustained IL-6 stimulation increased intracellular reactive oxygen species, repressed mitochondrial membrane potential (MMP), decreased intracellular content of ATP, and led to decreased SOD activity, an increase in iNOS protein expression, and increased protein expression of Pink1, Parkin, and Bnip3 involving in mitophagy, all of which were reversed by raloxifene.	Adenosine Triphosphate	161-164	interleukin 6	Mus musculus	10-14	
33824698-9	2021	Sustained IL-6 stimulation increased intracellular reactive oxygen species, repressed mitochondrial membrane potential (MMP), decreased intracellular content of ATP, and led to decreased SOD activity, an increase in iNOS protein expression, and increased protein expression of Pink1, Parkin, and Bnip3 involving in mitophagy, all of which were reversed by raloxifene.	Raloxifene Hydrochloride	356-366	interleukin 6	Mus musculus	10-14	
33824698-10	2021	Conclusion: Inflammation and IL-6/STAT3 signaling were activated in TAC-induced HF in mice, while sustained IL-6 incubation elicited oxidative stress and mitophagy-related protein increase in H9c2 myoblasts, all of which were inhibited by raloxifene.	tac	68-71	interleukin 6	Mus musculus	29-33	
33824698-10	2021	Conclusion: Inflammation and IL-6/STAT3 signaling were activated in TAC-induced HF in mice, while sustained IL-6 incubation elicited oxidative stress and mitophagy-related protein increase in H9c2 myoblasts, all of which were inhibited by raloxifene.	tac	68-71	signal transducer and activator of transcription 3	Mus musculus	34-39	
33824698-10	2021	Conclusion: Inflammation and IL-6/STAT3 signaling were activated in TAC-induced HF in mice, while sustained IL-6 incubation elicited oxidative stress and mitophagy-related protein increase in H9c2 myoblasts, all of which were inhibited by raloxifene.	Raloxifene Hydrochloride	239-249	interleukin 6	Mus musculus	108-112