PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33758737-1	2021	In the current study, the therapeutic potential of cerium oxide nanoparticles (nCeO2) was investigated in a human tau (htau) model of Alzheimer"s disease (AD), using Drosophila melanogaster as an in vivo model.	ceric oxide	51-63	microtubule associated protein tau	Homo sapiens	114-117	
33758737-4	2021	The synthesised nCeO2 were then administered as part of the diet to transgenic Drosophila for one month, at 0.1 and 1 mM concentrations, and its effect on the biochemical levels of superoxide dismutase (SOD), acetylcholinesterase (AChE), and the climbing activity of flies were studied in a pan-neuronal model (elav; htau) of AD.	nceo2	16-21	Superoxide dismutase 1	Drosophila melanogaster	203-206	
33758737-6	2021	Dietary administration of nCeO2 at a concentration of 1 mM restored the activity of SOD similar to that of control, but both concentrations of nCeO2 failed to modulate the level of AChE, and did not elicit any significant improvements in the climbing activity of elav; htau flies.	nceo2	26-31	Superoxide dismutase 1	Drosophila melanogaster	84-87	
33758737-8	2021	nCeO2 also elicited a significant decrease in htau gene expression at both concentrations and increased the mRNA expression of key autophagy genes ATG1 and ATG18.	nceo2	0-5	Autophagy-related 1	Drosophila melanogaster	147-151	
33758737-8	2021	nCeO2 also elicited a significant decrease in htau gene expression at both concentrations and increased the mRNA expression of key autophagy genes ATG1 and ATG18.	nceo2	0-5	Autophagy-related 18a	Drosophila melanogaster	156-161	
33758737-9	2021	The results therefore indicate that nCeO2 aids in replenishing the levels of SOD and tau clearance via the activation of autophagy.	nceo2	36-41	Superoxide dismutase 1	Drosophila melanogaster	77-80	
33758737-9	2021	The results therefore indicate that nCeO2 aids in replenishing the levels of SOD and tau clearance via the activation of autophagy.	nceo2	36-41	microtubule associated protein tau	Homo sapiens	85-88