PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3355579-0 1988 Identification of the hepatic cytochrome P-450 isozymes induced and decreased by picloram. Picloram 81-89 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 30-46 3355579-2 1988 These data are consistent with the assertion that picloram decreases the titer of hepatic male specific cytochrome P-450h. Picloram 50-58 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 115-121 3355579-3 1988 Several lines of evidence suggested that picloram is an inducer of hepatic cytochrome P-450 in male rats. Picloram 41-49 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 75-91 3355579-5 1988 This polypeptide co-migrated with protein bands which were correspondingly intensified after pretreatment with known inducers of cytochrome P-450d (3-methylcholanthrene and isosafrole). Methylcholanthrene 148-168 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 129-146 3355579-5 1988 This polypeptide co-migrated with protein bands which were correspondingly intensified after pretreatment with known inducers of cytochrome P-450d (3-methylcholanthrene and isosafrole). isosafrole 173-183 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 129-146 3355579-7 1988 Third, hepatic microsomes from picloram treated rats activated 2-amino-3-methylimidazo [4,5-f] quinoline (a cytochrome P-450d mediated catalysis) causing a 5-fold increase in the number of induced Salmonella typhimurium TA98 revertant colonies formed compared with control microsomes. Picloram 31-39 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 108-125 3355579-7 1988 Third, hepatic microsomes from picloram treated rats activated 2-amino-3-methylimidazo [4,5-f] quinoline (a cytochrome P-450d mediated catalysis) causing a 5-fold increase in the number of induced Salmonella typhimurium TA98 revertant colonies formed compared with control microsomes. 2-amino-3-methylimidazo(4,5-f)quinoline 63-104 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 108-125 3355579-8 1988 Fourth, the binding of n-octylamine to hepatic microsomes from picloram-treated rats showed, like microsomes from 3-methylcholanthrene-treated rats, an increase in the proportion of high-spin cytochrome P-450 present. octylamine 23-35 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 192-208 3355579-8 1988 Fourth, the binding of n-octylamine to hepatic microsomes from picloram-treated rats showed, like microsomes from 3-methylcholanthrene-treated rats, an increase in the proportion of high-spin cytochrome P-450 present. Picloram 63-71 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 192-208