PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33535038-6 2021 We identify vitamin C homeostasis as a critical regulator of ineffective erythropoiesis; oxidized ascorbate increases mitochondrial superoxide and significantly exacerbates the abnormal erythroblast phenotype of IDH1-downregulated progenitors, whereas vitamin C, scavenging reactive oxygen species (ROS) and reprogramming mitochondrial metabolism, rescues erythropoiesis. Reactive Oxygen Species 274-297 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 212-216 33535038-6 2021 We identify vitamin C homeostasis as a critical regulator of ineffective erythropoiesis; oxidized ascorbate increases mitochondrial superoxide and significantly exacerbates the abnormal erythroblast phenotype of IDH1-downregulated progenitors, whereas vitamin C, scavenging reactive oxygen species (ROS) and reprogramming mitochondrial metabolism, rescues erythropoiesis. Reactive Oxygen Species 299-302 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 212-216