PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33348310-0 2021 Diacerein protects rats with liver ischemia/reperfusion damage: Down-regulation of TLR4/ NFkappa-B signaling pathway. diacerein 0-9 toll-like receptor 4 Rattus norvegicus 83-87 33348310-8 2021 RESULTS: Diacerein pretreatment has the ability to restore the hepatic I/R damaging effect, proved by the reduction of serum liver enzymes, the decrease of the oxidative stress and hepatic inflammation via down-regulation of TLR4/ NFkappa-B signaling pathway together with the restoration of L-FABP level and improvement of the histopathological and immunohistochemical study findings in the hepatic tissue. diacerein 9-18 toll-like receptor 4 Rattus norvegicus 225-229 33348310-9 2021 CONCLUSION: These results suggested the hepatoprotective effect of diacerein relies on its antioxidant and anti-inflammatory effects reducing TLR4/ NFkappa-B signaling pathway. diacerein 67-76 toll-like receptor 4 Rattus norvegicus 142-146