PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33271594-1 2021 Caloric restriction (CR) has been shown repeatedly to prolong the lifespan in laboratory animals, with its benefits dependent on molecular targets forming part of the nutrient signaling network, including the NAD-dependent deacetylase silent mating type information regulation 2 homologue 1 (SIRT1). NAD 209-212 sirtuin 1 Mus musculus 292-297