PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33232283-0	2020	Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway.	Metformin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	90-94	
33232283-3	2020	In this study, we further examined the involvement of AMPK mediated activation of NLRP3 inflammasome in this cardioprotective effect of metformin.	Metformin	136-145	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	54-58	
33232283-8	2020	Furthermore, metformin activated phosphorylated AMPK, decreased pro-inflammatory cytokines, TNF-alpha, IL-6 and IL-1beta, and decreased NLRP3 inflammasome activation.	Metformin	13-22	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	48-52	
33232283-12	2020	Collectively, our study confirmed that metformin exerts cardioprotective effects by regulating myocardial I/R injury-induced inflammatory response, which was largely dependent on the enhancement of the AMPK pathway, thereby suppressing NLRP3 inflammasome activation.	Metformin	39-48	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	202-206