PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33227290-9 2021 We therefore hypothesised that the effect of metformin in vivo was not due to direct cytotoxicity on cancer cells, but by modulation of IGF-1 expression. Metformin 45-54 insulin like growth factor 1 Homo sapiens 136-141