PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33219891-5 2021 Near-identical inhibition of HIF-1alpha and HIF-2alpha and the regulation of downstream targets in VHL wild type and mutant cell lines demonstrated squalene efficacy beyond VHL-HIF interaction. Squalene 148-156 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 29-39 33219891-5 2021 Near-identical inhibition of HIF-1alpha and HIF-2alpha and the regulation of downstream targets in VHL wild type and mutant cell lines demonstrated squalene efficacy beyond VHL-HIF interaction. Squalene 148-156 endothelial PAS domain protein 1 Rattus norvegicus 44-54 33219891-5 2021 Near-identical inhibition of HIF-1alpha and HIF-2alpha and the regulation of downstream targets in VHL wild type and mutant cell lines demonstrated squalene efficacy beyond VHL-HIF interaction. Squalene 148-156 von Hippel-Lindau tumor suppressor Rattus norvegicus 99-102 33219891-6 2021 In a rat model of chemically induced RCC, squalene displayed chemopreventive capabilities by substantial reversal of lipid peroxidation, mitochondrial redox regulation, maintaining psim, inflammation [Akt, nuclear factor kappaB (NF-kappaB)], angiogenesis (VEGFalpha), metastasis [matrix metalloproteinase 2 (MMP-2)], and survival (Bax/Bcl2, cytochrome-c, Casp3). Squalene 42-50 AKT serine/threonine kinase 1 Rattus norvegicus 202-205 33219891-6 2021 In a rat model of chemically induced RCC, squalene displayed chemopreventive capabilities by substantial reversal of lipid peroxidation, mitochondrial redox regulation, maintaining psim, inflammation [Akt, nuclear factor kappaB (NF-kappaB)], angiogenesis (VEGFalpha), metastasis [matrix metalloproteinase 2 (MMP-2)], and survival (Bax/Bcl2, cytochrome-c, Casp3). Squalene 42-50 vascular endothelial growth factor A Rattus norvegicus 257-266 33219891-6 2021 In a rat model of chemically induced RCC, squalene displayed chemopreventive capabilities by substantial reversal of lipid peroxidation, mitochondrial redox regulation, maintaining psim, inflammation [Akt, nuclear factor kappaB (NF-kappaB)], angiogenesis (VEGFalpha), metastasis [matrix metalloproteinase 2 (MMP-2)], and survival (Bax/Bcl2, cytochrome-c, Casp3). Squalene 42-50 matrix metallopeptidase 2 Rattus norvegicus 281-307 33219891-6 2021 In a rat model of chemically induced RCC, squalene displayed chemopreventive capabilities by substantial reversal of lipid peroxidation, mitochondrial redox regulation, maintaining psim, inflammation [Akt, nuclear factor kappaB (NF-kappaB)], angiogenesis (VEGFalpha), metastasis [matrix metalloproteinase 2 (MMP-2)], and survival (Bax/Bcl2, cytochrome-c, Casp3). Squalene 42-50 matrix metallopeptidase 2 Rattus norvegicus 309-314 33219891-6 2021 In a rat model of chemically induced RCC, squalene displayed chemopreventive capabilities by substantial reversal of lipid peroxidation, mitochondrial redox regulation, maintaining psim, inflammation [Akt, nuclear factor kappaB (NF-kappaB)], angiogenesis (VEGFalpha), metastasis [matrix metalloproteinase 2 (MMP-2)], and survival (Bax/Bcl2, cytochrome-c, Casp3). Squalene 42-50 BCL2 associated X, apoptosis regulator Rattus norvegicus 332-335 33219891-6 2021 In a rat model of chemically induced RCC, squalene displayed chemopreventive capabilities by substantial reversal of lipid peroxidation, mitochondrial redox regulation, maintaining psim, inflammation [Akt, nuclear factor kappaB (NF-kappaB)], angiogenesis (VEGFalpha), metastasis [matrix metalloproteinase 2 (MMP-2)], and survival (Bax/Bcl2, cytochrome-c, Casp3). Squalene 42-50 BCL2, apoptosis regulator Rattus norvegicus 336-340 33219891-6 2021 In a rat model of chemically induced RCC, squalene displayed chemopreventive capabilities by substantial reversal of lipid peroxidation, mitochondrial redox regulation, maintaining psim, inflammation [Akt, nuclear factor kappaB (NF-kappaB)], angiogenesis (VEGFalpha), metastasis [matrix metalloproteinase 2 (MMP-2)], and survival (Bax/Bcl2, cytochrome-c, Casp3). Squalene 42-50 caspase 3 Rattus norvegicus 356-361 33219891-7 2021 Squalene restored glutathione, glutathione reductase, glutathione-s-transferase, catalase, and superoxide dismutase and stabilized alkaline phosphatase, alkaline transaminase, and aspartate transaminase. Squalene 0-8 glutathione-disulfide reductase Rattus norvegicus 31-52 33219891-7 2021 Squalene restored glutathione, glutathione reductase, glutathione-s-transferase, catalase, and superoxide dismutase and stabilized alkaline phosphatase, alkaline transaminase, and aspartate transaminase. Squalene 0-8 hematopoietic prostaglandin D synthase Rattus norvegicus 54-79 33219891-7 2021 Squalene restored glutathione, glutathione reductase, glutathione-s-transferase, catalase, and superoxide dismutase and stabilized alkaline phosphatase, alkaline transaminase, and aspartate transaminase. Squalene 0-8 catalase Rattus norvegicus 81-89 33219891-8 2021 The correlation of thiobarbituric acid reactive substance with VEGF/NF-kappaB and negative association of GSH with Casp3 show that squalene employs reduction in ROS regulation. thiobarbituric acid 19-38 vascular endothelial growth factor A Rattus norvegicus 63-67 33219891-8 2021 The correlation of thiobarbituric acid reactive substance with VEGF/NF-kappaB and negative association of GSH with Casp3 show that squalene employs reduction in ROS regulation. Squalene 131-139 vascular endothelial growth factor A Rattus norvegicus 63-67 33219891-8 2021 The correlation of thiobarbituric acid reactive substance with VEGF/NF-kappaB and negative association of GSH with Casp3 show that squalene employs reduction in ROS regulation. Squalene 131-139 caspase 3 Rattus norvegicus 115-120 33219891-8 2021 The correlation of thiobarbituric acid reactive substance with VEGF/NF-kappaB and negative association of GSH with Casp3 show that squalene employs reduction in ROS regulation. ros 161-164 caspase 3 Rattus norvegicus 115-120 33219891-14 2021 The significance of squalene effect for RCC is highlighted by its efficiency beyond VHL status, designating itself a promising drug candidate. Squalene 20-28 von Hippel-Lindau tumor suppressor Rattus norvegicus 84-87