PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33219891-5	2021	Near-identical inhibition of HIF-1alpha and HIF-2alpha and the regulation of downstream targets in VHL wild type and mutant cell lines demonstrated squalene efficacy beyond VHL-HIF interaction.	Squalene	148-156	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	29-39	
33219891-5	2021	Near-identical inhibition of HIF-1alpha and HIF-2alpha and the regulation of downstream targets in VHL wild type and mutant cell lines demonstrated squalene efficacy beyond VHL-HIF interaction.	Squalene	148-156	endothelial PAS domain protein 1	Rattus norvegicus	44-54	
33219891-5	2021	Near-identical inhibition of HIF-1alpha and HIF-2alpha and the regulation of downstream targets in VHL wild type and mutant cell lines demonstrated squalene efficacy beyond VHL-HIF interaction.	Squalene	148-156	von Hippel-Lindau tumor suppressor	Rattus norvegicus	99-102	
33219891-6	2021	In a rat model of chemically induced RCC, squalene displayed chemopreventive capabilities by substantial reversal of lipid peroxidation, mitochondrial redox regulation, maintaining  psim, inflammation [Akt, nuclear factor kappaB (NF-kappaB)], angiogenesis (VEGFalpha), metastasis [matrix metalloproteinase 2 (MMP-2)], and survival (Bax/Bcl2, cytochrome-c, Casp3).	Squalene	42-50	AKT serine/threonine kinase 1	Rattus norvegicus	202-205	
33219891-6	2021	In a rat model of chemically induced RCC, squalene displayed chemopreventive capabilities by substantial reversal of lipid peroxidation, mitochondrial redox regulation, maintaining  psim, inflammation [Akt, nuclear factor kappaB (NF-kappaB)], angiogenesis (VEGFalpha), metastasis [matrix metalloproteinase 2 (MMP-2)], and survival (Bax/Bcl2, cytochrome-c, Casp3).	Squalene	42-50	vascular endothelial growth factor A	Rattus norvegicus	257-266	
33219891-6	2021	In a rat model of chemically induced RCC, squalene displayed chemopreventive capabilities by substantial reversal of lipid peroxidation, mitochondrial redox regulation, maintaining  psim, inflammation [Akt, nuclear factor kappaB (NF-kappaB)], angiogenesis (VEGFalpha), metastasis [matrix metalloproteinase 2 (MMP-2)], and survival (Bax/Bcl2, cytochrome-c, Casp3).	Squalene	42-50	matrix metallopeptidase 2	Rattus norvegicus	281-307	
33219891-6	2021	In a rat model of chemically induced RCC, squalene displayed chemopreventive capabilities by substantial reversal of lipid peroxidation, mitochondrial redox regulation, maintaining  psim, inflammation [Akt, nuclear factor kappaB (NF-kappaB)], angiogenesis (VEGFalpha), metastasis [matrix metalloproteinase 2 (MMP-2)], and survival (Bax/Bcl2, cytochrome-c, Casp3).	Squalene	42-50	matrix metallopeptidase 2	Rattus norvegicus	309-314	
33219891-6	2021	In a rat model of chemically induced RCC, squalene displayed chemopreventive capabilities by substantial reversal of lipid peroxidation, mitochondrial redox regulation, maintaining  psim, inflammation [Akt, nuclear factor kappaB (NF-kappaB)], angiogenesis (VEGFalpha), metastasis [matrix metalloproteinase 2 (MMP-2)], and survival (Bax/Bcl2, cytochrome-c, Casp3).	Squalene	42-50	BCL2 associated X, apoptosis regulator	Rattus norvegicus	332-335	
33219891-6	2021	In a rat model of chemically induced RCC, squalene displayed chemopreventive capabilities by substantial reversal of lipid peroxidation, mitochondrial redox regulation, maintaining  psim, inflammation [Akt, nuclear factor kappaB (NF-kappaB)], angiogenesis (VEGFalpha), metastasis [matrix metalloproteinase 2 (MMP-2)], and survival (Bax/Bcl2, cytochrome-c, Casp3).	Squalene	42-50	BCL2, apoptosis regulator	Rattus norvegicus	336-340	
33219891-6	2021	In a rat model of chemically induced RCC, squalene displayed chemopreventive capabilities by substantial reversal of lipid peroxidation, mitochondrial redox regulation, maintaining  psim, inflammation [Akt, nuclear factor kappaB (NF-kappaB)], angiogenesis (VEGFalpha), metastasis [matrix metalloproteinase 2 (MMP-2)], and survival (Bax/Bcl2, cytochrome-c, Casp3).	Squalene	42-50	caspase 3	Rattus norvegicus	356-361	
33219891-7	2021	Squalene restored glutathione, glutathione reductase, glutathione-s-transferase, catalase, and superoxide dismutase and stabilized alkaline phosphatase, alkaline transaminase, and aspartate transaminase.	Squalene	0-8	glutathione-disulfide reductase	Rattus norvegicus	31-52	
33219891-7	2021	Squalene restored glutathione, glutathione reductase, glutathione-s-transferase, catalase, and superoxide dismutase and stabilized alkaline phosphatase, alkaline transaminase, and aspartate transaminase.	Squalene	0-8	hematopoietic prostaglandin D synthase	Rattus norvegicus	54-79	
33219891-7	2021	Squalene restored glutathione, glutathione reductase, glutathione-s-transferase, catalase, and superoxide dismutase and stabilized alkaline phosphatase, alkaline transaminase, and aspartate transaminase.	Squalene	0-8	catalase	Rattus norvegicus	81-89	
33219891-8	2021	The correlation of thiobarbituric acid reactive substance with VEGF/NF-kappaB and negative association of GSH with Casp3 show that squalene employs reduction in ROS regulation.	thiobarbituric acid	19-38	vascular endothelial growth factor A	Rattus norvegicus	63-67	
33219891-8	2021	The correlation of thiobarbituric acid reactive substance with VEGF/NF-kappaB and negative association of GSH with Casp3 show that squalene employs reduction in ROS regulation.	Squalene	131-139	vascular endothelial growth factor A	Rattus norvegicus	63-67	
33219891-8	2021	The correlation of thiobarbituric acid reactive substance with VEGF/NF-kappaB and negative association of GSH with Casp3 show that squalene employs reduction in ROS regulation.	Squalene	131-139	caspase 3	Rattus norvegicus	115-120	
33219891-8	2021	The correlation of thiobarbituric acid reactive substance with VEGF/NF-kappaB and negative association of GSH with Casp3 show that squalene employs reduction in ROS regulation.	ros	161-164	caspase 3	Rattus norvegicus	115-120	
33219891-14	2021	The significance of squalene effect for RCC is highlighted by its efficiency beyond VHL status, designating itself a promising drug candidate.	Squalene	20-28	von Hippel-Lindau tumor suppressor	Rattus norvegicus	84-87