PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33210730-0 2021 Circadian Photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons via Melatonin Receptor 1 signaling. Melatonin 109-118 potassium channel, subfamily K, member 2 Mus musculus 29-35 33210730-3 2021 Here we focus on the possible ionic mechanisms that underlie the observed programming of the electrophysiological properties of serotonin neurons, focusing on the twin-pore K+ channels TREK-1 and TASK-1 that set resting membrane potential and regulate excitability. Serotonin 128-137 potassium channel, subfamily K, member 2 Mus musculus 185-191 33210730-6 2021 We then quantified Kcnk2 mRNA levels specifically in dorsal raphe 5-HT neurons using triple-label RNAscope. Serotonin 66-70 potassium channel, subfamily K, member 2 Mus musculus 19-24 33210730-7 2021 We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons. Serotonin 72-81 potassium channel, subfamily K, member 2 Mus musculus 63-68 33210730-7 2021 We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons. Serotonin 72-81 tryptophan hydroxylase 2 Mus musculus 104-108 33210730-7 2021 We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons. Serotonin 72-81 potassium channel, subfamily K, member 2 Mus musculus 177-183 33210730-7 2021 We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons. Melatonin 200-209 potassium channel, subfamily K, member 2 Mus musculus 63-68 33210730-7 2021 We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons. Melatonin 200-209 plasmacytoma expressed transcript 1 Mus musculus 114-119 33210730-7 2021 We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons. Melatonin 200-209 potassium channel, subfamily K, member 2 Mus musculus 177-183 33210730-7 2021 We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons. Melatonin 200-209 metallothionein 1 Mus musculus 231-235 33210730-7 2021 We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons. Serotonin 358-362 potassium channel, subfamily K, member 2 Mus musculus 63-68 33210730-7 2021 We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons. Serotonin 358-362 potassium channel, subfamily K, member 2 Mus musculus 177-183 33210730-8 2021 Taken together these results indicate that photoperiodic regulation of TREK-1 expression and function plays a key role in photoperiodic programming the excitability of dorsal raphe 5-HT neurons. Serotonin 181-185 potassium channel, subfamily K, member 2 Mus musculus 71-77