PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33210730-0	2021	Circadian Photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons via Melatonin Receptor 1 signaling.	Melatonin	109-118	potassium channel, subfamily K, member 2	Mus musculus	29-35	
33210730-3	2021	Here we focus on the possible ionic mechanisms that underlie the observed programming of the electrophysiological properties of serotonin neurons, focusing on the twin-pore K+ channels TREK-1 and TASK-1 that set resting membrane potential and regulate excitability.	Serotonin	128-137	potassium channel, subfamily K, member 2	Mus musculus	185-191	
33210730-6	2021	We then quantified Kcnk2 mRNA levels specifically in dorsal raphe 5-HT neurons using triple-label RNAscope.	Serotonin	66-70	potassium channel, subfamily K, member 2	Mus musculus	19-24	
33210730-7	2021	We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons.	Serotonin	72-81	potassium channel, subfamily K, member 2	Mus musculus	63-68	
33210730-7	2021	We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons.	Serotonin	72-81	tryptophan hydroxylase 2	Mus musculus	104-108	
33210730-7	2021	We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons.	Serotonin	72-81	potassium channel, subfamily K, member 2	Mus musculus	177-183	
33210730-7	2021	We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons.	Melatonin	200-209	potassium channel, subfamily K, member 2	Mus musculus	63-68	
33210730-7	2021	We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons.	Melatonin	200-209	plasmacytoma expressed transcript 1	Mus musculus	114-119	
33210730-7	2021	We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons.	Melatonin	200-209	potassium channel, subfamily K, member 2	Mus musculus	177-183	
33210730-7	2021	We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons.	Melatonin	200-209	metallothionein 1	Mus musculus	231-235	
33210730-7	2021	We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons.	Serotonin	358-362	potassium channel, subfamily K, member 2	Mus musculus	63-68	
33210730-7	2021	We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons.	Serotonin	358-362	potassium channel, subfamily K, member 2	Mus musculus	177-183	
33210730-8	2021	Taken together these results indicate that photoperiodic regulation of TREK-1 expression and function plays a key role in photoperiodic programming the excitability of dorsal raphe 5-HT neurons.	Serotonin	181-185	potassium channel, subfamily K, member 2	Mus musculus	71-77