PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33191463-3	2020	To further increase D-limonene formation, the metabolic flux of the mevalonate (MVA) pathway was enhanced by overexpressing the key genes tHMGR1, ERG12, IDI1, and IDI1WWW, respectively, or co-overexpressing.	Mevalonic Acid	68-78	mevalonate kinase	Saccharomyces cerevisiae S288C	146-151	
33191463-3	2020	To further increase D-limonene formation, the metabolic flux of the mevalonate (MVA) pathway was enhanced by overexpressing the key genes tHMGR1, ERG12, IDI1, and IDI1WWW, respectively, or co-overexpressing.	Mevalonic Acid	68-78	isopentenyl-diphosphate delta-isomerase IDI1	Saccharomyces cerevisiae S288C	153-157	
33191463-3	2020	To further increase D-limonene formation, the metabolic flux of the mevalonate (MVA) pathway was enhanced by overexpressing the key genes tHMGR1, ERG12, IDI1, and IDI1WWW, respectively, or co-overexpressing.	Mevalonic Acid	68-78	isopentenyl-diphosphate delta-isomerase IDI1	Saccharomyces cerevisiae S288C	163-167	
33191463-3	2020	To further increase D-limonene formation, the metabolic flux of the mevalonate (MVA) pathway was enhanced by overexpressing the key genes tHMGR1, ERG12, IDI1, and IDI1WWW, respectively, or co-overexpressing.	Mevalonic Acid	80-83	mevalonate kinase	Saccharomyces cerevisiae S288C	146-151	
33191463-3	2020	To further increase D-limonene formation, the metabolic flux of the mevalonate (MVA) pathway was enhanced by overexpressing the key genes tHMGR1, ERG12, IDI1, and IDI1WWW, respectively, or co-overexpressing.	Mevalonic Acid	80-83	isopentenyl-diphosphate delta-isomerase IDI1	Saccharomyces cerevisiae S288C	153-157	
33191463-3	2020	To further increase D-limonene formation, the metabolic flux of the mevalonate (MVA) pathway was enhanced by overexpressing the key genes tHMGR1, ERG12, IDI1, and IDI1WWW, respectively, or co-overexpressing.	Mevalonic Acid	80-83	isopentenyl-diphosphate delta-isomerase IDI1	Saccharomyces cerevisiae S288C	163-167	
33191463-4	2020	The results showed that strengthening the MVA pathway significantly improved D-limonene production, while the best strain yielded 62.31 mg/L D-limonene by co-expressing tHMGR1, ERG12, and IDI1WWW genes in alcoholic beverages.	Limonene	141-151	mevalonate kinase	Saccharomyces cerevisiae S288C	177-182	
33191463-4	2020	The results showed that strengthening the MVA pathway significantly improved D-limonene production, while the best strain yielded 62.31 mg/L D-limonene by co-expressing tHMGR1, ERG12, and IDI1WWW genes in alcoholic beverages.	Limonene	141-151	isopentenyl-diphosphate delta-isomerase IDI1	Saccharomyces cerevisiae S288C	188-192	
33191463-6	2020	Besides, to further resolve the problem of yeast growth inhibition, we separately investigated transporter proteins of the high-yielding D-limonene yeasts and the parental strain under the stress of different D-limonene concentration, suggesting that the transporters of Aus1p, Pdr18p, Pdr5p, Pdr3p, Pdr11p, Pdr15p, Tpo1p, and Ste6p might play a more critical role in alleviating cytotoxicity and improving the tolerance to D-limonene.	Limonene	137-147	ATP-binding cassette sterol transporter AUS1	Saccharomyces cerevisiae S288C	271-276	
33191463-6	2020	Besides, to further resolve the problem of yeast growth inhibition, we separately investigated transporter proteins of the high-yielding D-limonene yeasts and the parental strain under the stress of different D-limonene concentration, suggesting that the transporters of Aus1p, Pdr18p, Pdr5p, Pdr3p, Pdr11p, Pdr15p, Tpo1p, and Ste6p might play a more critical role in alleviating cytotoxicity and improving the tolerance to D-limonene.	Limonene	137-147	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	278-284	
33191463-6	2020	Besides, to further resolve the problem of yeast growth inhibition, we separately investigated transporter proteins of the high-yielding D-limonene yeasts and the parental strain under the stress of different D-limonene concentration, suggesting that the transporters of Aus1p, Pdr18p, Pdr5p, Pdr3p, Pdr11p, Pdr15p, Tpo1p, and Ste6p might play a more critical role in alleviating cytotoxicity and improving the tolerance to D-limonene.	Limonene	137-147	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	286-291	
33191463-6	2020	Besides, to further resolve the problem of yeast growth inhibition, we separately investigated transporter proteins of the high-yielding D-limonene yeasts and the parental strain under the stress of different D-limonene concentration, suggesting that the transporters of Aus1p, Pdr18p, Pdr5p, Pdr3p, Pdr11p, Pdr15p, Tpo1p, and Ste6p might play a more critical role in alleviating cytotoxicity and improving the tolerance to D-limonene.	Limonene	137-147	drug-responsive transcription factor PDR3	Saccharomyces cerevisiae S288C	293-298	
33191463-6	2020	Besides, to further resolve the problem of yeast growth inhibition, we separately investigated transporter proteins of the high-yielding D-limonene yeasts and the parental strain under the stress of different D-limonene concentration, suggesting that the transporters of Aus1p, Pdr18p, Pdr5p, Pdr3p, Pdr11p, Pdr15p, Tpo1p, and Ste6p might play a more critical role in alleviating cytotoxicity and improving the tolerance to D-limonene.	Limonene	137-147	ATP-binding cassette multidrug transporter PDR11	Saccharomyces cerevisiae S288C	300-306	
33191463-6	2020	Besides, to further resolve the problem of yeast growth inhibition, we separately investigated transporter proteins of the high-yielding D-limonene yeasts and the parental strain under the stress of different D-limonene concentration, suggesting that the transporters of Aus1p, Pdr18p, Pdr5p, Pdr3p, Pdr11p, Pdr15p, Tpo1p, and Ste6p might play a more critical role in alleviating cytotoxicity and improving the tolerance to D-limonene.	Limonene	137-147	ATP-binding cassette multidrug transporter PDR15	Saccharomyces cerevisiae S288C	308-314	
33191463-6	2020	Besides, to further resolve the problem of yeast growth inhibition, we separately investigated transporter proteins of the high-yielding D-limonene yeasts and the parental strain under the stress of different D-limonene concentration, suggesting that the transporters of Aus1p, Pdr18p, Pdr5p, Pdr3p, Pdr11p, Pdr15p, Tpo1p, and Ste6p might play a more critical role in alleviating cytotoxicity and improving the tolerance to D-limonene.	Limonene	137-147	Tpo1p	Saccharomyces cerevisiae S288C	316-321	
33191463-6	2020	Besides, to further resolve the problem of yeast growth inhibition, we separately investigated transporter proteins of the high-yielding D-limonene yeasts and the parental strain under the stress of different D-limonene concentration, suggesting that the transporters of Aus1p, Pdr18p, Pdr5p, Pdr3p, Pdr11p, Pdr15p, Tpo1p, and Ste6p might play a more critical role in alleviating cytotoxicity and improving the tolerance to D-limonene.	Limonene	137-147	ATP-binding cassette a-factor transporter STE6	Saccharomyces cerevisiae S288C	327-332	
33191463-6	2020	Besides, to further resolve the problem of yeast growth inhibition, we separately investigated transporter proteins of the high-yielding D-limonene yeasts and the parental strain under the stress of different D-limonene concentration, suggesting that the transporters of Aus1p, Pdr18p, Pdr5p, Pdr3p, Pdr11p, Pdr15p, Tpo1p, and Ste6p might play a more critical role in alleviating cytotoxicity and improving the tolerance to D-limonene.	Limonene	209-219	ATP-binding cassette sterol transporter AUS1	Saccharomyces cerevisiae S288C	271-276	
33191463-6	2020	Besides, to further resolve the problem of yeast growth inhibition, we separately investigated transporter proteins of the high-yielding D-limonene yeasts and the parental strain under the stress of different D-limonene concentration, suggesting that the transporters of Aus1p, Pdr18p, Pdr5p, Pdr3p, Pdr11p, Pdr15p, Tpo1p, and Ste6p might play a more critical role in alleviating cytotoxicity and improving the tolerance to D-limonene.	Limonene	209-219	ATP-binding cassette sterol transporter AUS1	Saccharomyces cerevisiae S288C	271-276	
33191463-7	2020	Finally, we verified the functions of three transporter proteins, finding that the transporter of Aus1p failed to transport D-limonene, and the others (Pdr5p and Pdr15p) could improve the tolerance of yeast to D-limonene.	Limonene	124-134	ATP-binding cassette sterol transporter AUS1	Saccharomyces cerevisiae S288C	98-103	
33191463-7	2020	Finally, we verified the functions of three transporter proteins, finding that the transporter of Aus1p failed to transport D-limonene, and the others (Pdr5p and Pdr15p) could improve the tolerance of yeast to D-limonene.	Limonene	210-220	ATP-binding cassette sterol transporter AUS1	Saccharomyces cerevisiae S288C	98-103	
33191463-7	2020	Finally, we verified the functions of three transporter proteins, finding that the transporter of Aus1p failed to transport D-limonene, and the others (Pdr5p and Pdr15p) could improve the tolerance of yeast to D-limonene.	Limonene	210-220	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	152-157	
33191463-7	2020	Finally, we verified the functions of three transporter proteins, finding that the transporter of Aus1p failed to transport D-limonene, and the others (Pdr5p and Pdr15p) could improve the tolerance of yeast to D-limonene.	Limonene	210-220	ATP-binding cassette multidrug transporter PDR15	Saccharomyces cerevisiae S288C	162-168