PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33029288-0	2020	Induction of cytoprotective autophagy by morusin via AMP-activated protein kinase activation in human non-small cell lung cancer cells.	morusin	41-48	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	53-81	
33029288-4	2020	The role of autophagy and AMP-activated protein kinase (AMPK) was determined by treating NSCLC cells with bafilomycin A1, an autophagy inhibitor, and compound C, an AMPK inhibitor.	bafilomycin A1	106-120	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	56-60	
33029288-6	2020	RESULTS: Morusin increased the formation of LC3 puncta in the cytoplasm and upregulated the expression of autophagy-related 5 (Atg5), Atg12, beclin-1, and LC3II in NSCLC cells, demonstrating that morusin could induce autophagy.	morusin	9-16	autophagy related 5	Homo sapiens	106-125	
33029288-6	2020	RESULTS: Morusin increased the formation of LC3 puncta in the cytoplasm and upregulated the expression of autophagy-related 5 (Atg5), Atg12, beclin-1, and LC3II in NSCLC cells, demonstrating that morusin could induce autophagy.	morusin	9-16	autophagy related 5	Homo sapiens	127-131	
33029288-6	2020	RESULTS: Morusin increased the formation of LC3 puncta in the cytoplasm and upregulated the expression of autophagy-related 5 (Atg5), Atg12, beclin-1, and LC3II in NSCLC cells, demonstrating that morusin could induce autophagy.	morusin	9-16	autophagy related 12	Homo sapiens	134-139	
33029288-6	2020	RESULTS: Morusin increased the formation of LC3 puncta in the cytoplasm and upregulated the expression of autophagy-related 5 (Atg5), Atg12, beclin-1, and LC3II in NSCLC cells, demonstrating that morusin could induce autophagy.	morusin	9-16	beclin 1	Homo sapiens	141-149	
33029288-7	2020	Treatment with bafilomycin A1 markedly reduced cell viability but increased proportions of sub-G1 phase cells and annexin V-positive cells in H460 cells.	bafilomycin A1	15-29	annexin A5	Homo sapiens	114-123	
33029288-9	2020	Furthermore, we found that AMPK and its downstream acetyl-CoA carboxylase (ACC) were phosphorylated, while mammalian target of rapamycin (mTOR) and its downstream p70S6 kinase (p70S6K) were dephosphorylated by morusin.	morusin	210-217	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	27-31	
33029288-9	2020	Furthermore, we found that AMPK and its downstream acetyl-CoA carboxylase (ACC) were phosphorylated, while mammalian target of rapamycin (mTOR) and its downstream p70S6 kinase (p70S6K) were dephosphorylated by morusin.	morusin	210-217	mechanistic target of rapamycin kinase	Homo sapiens	107-136	
33029288-9	2020	Furthermore, we found that AMPK and its downstream acetyl-CoA carboxylase (ACC) were phosphorylated, while mammalian target of rapamycin (mTOR) and its downstream p70S6 kinase (p70S6K) were dephosphorylated by morusin.	morusin	210-217	mechanistic target of rapamycin kinase	Homo sapiens	138-142	
33029288-9	2020	Furthermore, we found that AMPK and its downstream acetyl-CoA carboxylase (ACC) were phosphorylated, while mammalian target of rapamycin (mTOR) and its downstream p70S6 kinase (p70S6K) were dephosphorylated by morusin.	morusin	210-217	ribosomal protein S6 kinase B1	Homo sapiens	163-175	
33029288-9	2020	Furthermore, we found that AMPK and its downstream acetyl-CoA carboxylase (ACC) were phosphorylated, while mammalian target of rapamycin (mTOR) and its downstream p70S6 kinase (p70S6K) were dephosphorylated by morusin.	morusin	210-217	ribosomal protein S6 kinase B1	Homo sapiens	177-183	
33029288-11	2020	These results suggest that morusin-induced AMPK activation could protect NSCLC cells from apoptosis probably by inducing autophagy.	morusin	27-34	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	43-47	
33029288-12	2020	CONCLUSIONS: Our findings suggest that combination treatment with morusin and autophagy inhibitor or AMPK inhibitor might enhance the clinical efficacy of morusin for NSCLC.	morusin	155-162	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	101-105