PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32976869-1 2021 BACKGROUND AND PURPOSE: This phase 1 trial aimed to determine the maximum tolerated dose (MTD; primary objective) of a p38-MAPK inhibitor, ralimetinib, with radiotherapy (RT) and chemotherapy (TMZ), in the treatment of newly diagnosed glioblastoma (GBM) patients. Ralimetinib 139-150 mitogen-activated protein kinase 14 Homo sapiens 119-127 32976869-11 2021 CONCLUSION: This phase 1 trial is the first trial to study the combination of a p38-MAPK inhibitor, ralimetinib, with radiotherapy (RT) and chemotherapy (TMZ), in the treatment of newly diagnosed glioblastoma (GBM) patients. Ralimetinib 100-111 mitogen-activated protein kinase 14 Homo sapiens 80-88