PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32945455-2 2020 Studies have indicated that ginsenoside Rg1, a primary component of ginseng (Panax ginseng), reduces brain Aβ levels in an AD model through peroxisome proliferator-activated receptor γ (PPARγ), thereby regulating the expression of insulin-degrading enzyme (Ide) and β-amyloid cleavage enzyme 1 (Bace1), which are PPARγ target genes. ginsenoside Rg1 28-43 beta-secretase 1 Rattus norvegicus 322-327 32945455-10 2020 The results of the present study demonstrated that in an AD model induced by Aβ1-42, ginsenoside Rg1 significantly decreased CDK5 expression, inhibited PPARγ phosphorylation at serine 273, elevated IDE expression, downregulated BACE1 and APP expression, decreased Aβ1-42 levels and attenuated neuronal apoptosis. ginsenoside Rg1 90-105 beta-secretase 1 Rattus norvegicus 239-244