PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32790873-3 2020 OBJECTIVES: To evaluate the activity of carbapenems alone or combined with DMSA against MBL-producing Escherichia coli in a severe murine peritonitis model. Succimer 75-79 mannose-binding lectin (protein C) 2 Mus musculus 88-91 32790873-7 2020 Bacterial counts in peritoneal fluid and spleen were assessed at 24 h. RESULTS: DMSA in combination with each carbapenem caused a significant decrease in the MICs for all MBL-producing strains, in a concentration-dependent manner, but did not provide benefit against non-MBL strains. Succimer 80-84 mannose-binding lectin (protein C) 2 Mus musculus 171-174 32790873-7 2020 Bacterial counts in peritoneal fluid and spleen were assessed at 24 h. RESULTS: DMSA in combination with each carbapenem caused a significant decrease in the MICs for all MBL-producing strains, in a concentration-dependent manner, but did not provide benefit against non-MBL strains. Succimer 80-84 mannose-binding lectin (protein C) 2 Mus musculus 271-274 32790873-10 2020 CONCLUSIONS: DMSA restores the activity of carbapenems against MBL-producing strains, and its combination with carbapenems appears to be a promising strategy for the treatment of NDM-producing E. coli infections. Succimer 13-17 mannose-binding lectin (protein C) 2 Mus musculus 63-66