PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32772615-1 2022 Background: Calcium-binding proteins are heterogeneous proteins that act binding this ion in specific domains, performing numerous functions.Objective: In the present review, we aim to gather principal information about S100B protein in the Central Nervous System (CNS), highlighting its particularities, mapping, functionalities, and consequences on CNS dysfunction.Methods: The research was carried out by searching Pubmed, Medline, Science Direct, Lilacs, the Cochrane Library, and Web of Science databases using the following descriptors: S100 protein; Central Nervous System; Nervous Lesions, as well as their corresponding terms in Portuguese and Spanish. Calcium 12-19 S100 calcium binding protein B Homo sapiens 220-225 32772615-1 2022 Background: Calcium-binding proteins are heterogeneous proteins that act binding this ion in specific domains, performing numerous functions.Objective: In the present review, we aim to gather principal information about S100B protein in the Central Nervous System (CNS), highlighting its particularities, mapping, functionalities, and consequences on CNS dysfunction.Methods: The research was carried out by searching Pubmed, Medline, Science Direct, Lilacs, the Cochrane Library, and Web of Science databases using the following descriptors: S100 protein; Central Nervous System; Nervous Lesions, as well as their corresponding terms in Portuguese and Spanish. Calcium 12-19 S100 calcium binding protein B Homo sapiens 220-224 32772615-2 2022 The terms were first searched separately, then together.Results: Due to its ability to bind with calcium, S100B is involved in the regulation of several intra- and extracellular physiological processes. Calcium 97-104 S100 calcium binding protein B Homo sapiens 106-111