PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32252811-0 2020 Everolimus versus alpelisib in advanced hormone receptor-positive HER2-negative breast cancer: targeting different nodes of the PI3K/AKT/mTORC1 pathway with different clinical implications. Everolimus 0-10 CREB regulated transcription coactivator 1 Mus musculus 137-143 32252811-2 2020 Based on results of the BOLERO-2 trial, the mTORC1 inhibitor everolimus in combination with the steroidal aromatase inhibitor (AI) exemestane has become a standard treatment for patients with HR+ HER2- mBC resistant to prior non-steroidal AI therapy. Everolimus 61-71 CREB regulated transcription coactivator 1 Mus musculus 44-50 32252811-4 2020 Therefore, two different molecules targeting the PI3K/AKT/mTORC1 axis, namely everolimus and alpelisib, are available for patients progressing on/after previous AI treatment, but it is unclear how to optimize their use in the clinical practice. Everolimus 78-88 CREB regulated transcription coactivator 1 Mus musculus 58-64