PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32176932-8 2021 RESULTS: The results demonstrated that the effect of HFD on inflammatory cytokines in mice with apoE-/- background was reversed by celastrol administration, and celastrol treatment inhibited the NOD-like receptor family, pyrin domain containing 3 (NLRP3)/caspase-1/interleukin-1beta signaling cascades in peripheral blood mononuclear cells from HFD-fed apoE-/- mice. celastrol 161-170 interleukin 1 beta Mus musculus 265-282