PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31956373-0	2020	Nicotine Upregulates the Level of Mcl-1 through STAT3 in H1299 Cells.	Nicotine	0-8	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	34-39	
31956373-1	2020	Background: Nicotine contributes to development of human lung cancer and chemoresistance through activation of myeloid cell leukemia-1 (Mcl-1).	Nicotine	12-20	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	111-134	
31956373-1	2020	Background: Nicotine contributes to development of human lung cancer and chemoresistance through activation of myeloid cell leukemia-1 (Mcl-1).	Nicotine	12-20	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	136-141	
31956373-3	2020	Therefore, we examined the STAT3 cascade in nicotine regulation of Mcl-1 transcription in human lung cancer cells.	Nicotine	44-52	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	67-72	
31956373-4	2020	Methods: The effects of nicotine on the expression of STAT3 and Mcl-1 were determined using western blot.	Nicotine	24-32	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	64-69	
31956373-7	2020	Results: STAT3 was constitutively activated (i.e., tyrosine-phosphorylated, serine-phosphorylated and nuclear translocation), meanwhile the expression and transcriptional activity of Mcl-1 were up-regulated in lung cancer cells following treatment with nicotine.	Nicotine	253-261	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	183-188	
31956373-9	2020	Deleted mutagenesis of a putative STAT3 consensus binding sequence decreased Mcl-1 promoter activity and eliminated the increase of Mcl-1 promoter activity induced by nicotine.	Nicotine	167-175	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	132-137	
31956373-12	2020	Conclusions: We have demonstrated that nicotine induces up-regulation of Mcl-1 through STAT3, which process may be independent on JAKs and not only dependent on the phosphorylation of Y705.	Nicotine	39-47	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	73-78