PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31945013-6 2020 In addition, metformin treatment decreased p16INK4a levels in OA chondrocytes, and enhanced polarization of AMPK and inhibition of mTORC1 in OA mice and chondrocytes in a dose-dependent manner. Metformin 13-22 CREB regulated transcription coactivator 1 Mus musculus 131-137