PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31885317-0 2020 The long noncoding RNA CRAL reverses cisplatin resistance via the miR-505/CYLD/AKT axis in human gastric cancer cells. Cisplatin 37-46 AKT serine/threonine kinase 1 Homo sapiens 79-82 31885317-5 2020 Moreover, a specific small molecule inhibitor of AKT activation, MK2206, effectively reversed the cisplatin resistance in GC caused by CRAL deficiency. Cisplatin 98-107 AKT serine/threonine kinase 1 Homo sapiens 49-52 31885317-6 2020 In conclusion, we provide the first evidence that a novel lncRNA, CRAL, could function as a competing endogenous RNA (ceRNA) to reverse GC cisplatin resistance via the miR-505/CYLD/AKT axis, which suggests that CRAL could be considered a potential predictive biomarker and therapeutic target for cisplatin resistance in gastric cancer. Cisplatin 139-148 AKT serine/threonine kinase 1 Homo sapiens 181-184 31885317-6 2020 In conclusion, we provide the first evidence that a novel lncRNA, CRAL, could function as a competing endogenous RNA (ceRNA) to reverse GC cisplatin resistance via the miR-505/CYLD/AKT axis, which suggests that CRAL could be considered a potential predictive biomarker and therapeutic target for cisplatin resistance in gastric cancer. Cisplatin 296-305 AKT serine/threonine kinase 1 Homo sapiens 181-184