PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31852219-3 2020 We, and others, previously demonstrated that microRNA-144 (miR-144) functions to post-transcriptionally regulate ABCA1 (ATP binding cassette transporter A1) and plasma HDL (high-density lipoprotein) cholesterol levels. Cholesterol 199-210 microRNA 144 Mus musculus 45-57 31852219-3 2020 We, and others, previously demonstrated that microRNA-144 (miR-144) functions to post-transcriptionally regulate ABCA1 (ATP binding cassette transporter A1) and plasma HDL (high-density lipoprotein) cholesterol levels. Cholesterol 199-210 microRNA 144 Mus musculus 59-66 31852219-6 2020 MiR-144 antagonism increased circulating HDL cholesterol levels, remodeled the HDL particle, and enhanced reverse cholesterol transport. Cholesterol 45-56 microRNA 144 Mus musculus 0-7 31852219-6 2020 MiR-144 antagonism increased circulating HDL cholesterol levels, remodeled the HDL particle, and enhanced reverse cholesterol transport. Cholesterol 114-125 microRNA 144 Mus musculus 0-7 31852219-7 2020 Notably, the effects on HDL and reverse cholesterol transport were more pronounced in male mice suggesting sex-specific differences may contribute to the effects of silencing miR-144 on atherosclerosis. Cholesterol 40-51 microRNA 144 Mus musculus 175-182 31852219-8 2020 As a molecular mechanism, we identify the oxysterol metabolizing enzyme CYP7B1 (cytochrome P450 enzyme 7B1) as a miR-144 regulated gene in male, but not female mice. arthrofactin 42-51 cytochrome P450, family 7, subfamily b, polypeptide 1 Mus musculus 72-78 31852219-8 2020 As a molecular mechanism, we identify the oxysterol metabolizing enzyme CYP7B1 (cytochrome P450 enzyme 7B1) as a miR-144 regulated gene in male, but not female mice. arthrofactin 42-51 cytochrome P450, family 7, subfamily b, polypeptide 1 Mus musculus 80-106 31852219-8 2020 As a molecular mechanism, we identify the oxysterol metabolizing enzyme CYP7B1 (cytochrome P450 enzyme 7B1) as a miR-144 regulated gene in male, but not female mice. arthrofactin 42-51 microRNA 144 Mus musculus 113-120 31852219-9 2020 Consistent with miR-144-dependent changes in CYP7B1 activity, we show decreased levels of 27-hydroxycholesterol, a known proatherogenic sterol and the endogenous substrate for CYP7B1 in male, but not female mice. Hydroxycholesterols 93-111 microRNA 144 Mus musculus 16-23 31852219-9 2020 Consistent with miR-144-dependent changes in CYP7B1 activity, we show decreased levels of 27-hydroxycholesterol, a known proatherogenic sterol and the endogenous substrate for CYP7B1 in male, but not female mice. Sterols 105-111 microRNA 144 Mus musculus 16-23 31852219-9 2020 Consistent with miR-144-dependent changes in CYP7B1 activity, we show decreased levels of 27-hydroxycholesterol, a known proatherogenic sterol and the endogenous substrate for CYP7B1 in male, but not female mice. Sterols 105-111 cytochrome P450, family 7, subfamily b, polypeptide 1 Mus musculus 45-51 31852219-9 2020 Consistent with miR-144-dependent changes in CYP7B1 activity, we show decreased levels of 27-hydroxycholesterol, a known proatherogenic sterol and the endogenous substrate for CYP7B1 in male, but not female mice. Sterols 105-111 cytochrome P450, family 7, subfamily b, polypeptide 1 Mus musculus 176-182 31852219-10 2020 CONCLUSIONS: Our data demonstrate silencing miR-144 has sex-specific effects and that treatment with antisense oligonucleotides to target miR-144 might result in enhancements in reverse cholesterol transport and oxysterol metabolism in patients with cardiovascular disease. Cholesterol 186-197 microRNA 144 Homo sapiens 44-51 31852219-10 2020 CONCLUSIONS: Our data demonstrate silencing miR-144 has sex-specific effects and that treatment with antisense oligonucleotides to target miR-144 might result in enhancements in reverse cholesterol transport and oxysterol metabolism in patients with cardiovascular disease. Cholesterol 186-197 microRNA 144 Homo sapiens 138-145 31852219-10 2020 CONCLUSIONS: Our data demonstrate silencing miR-144 has sex-specific effects and that treatment with antisense oligonucleotides to target miR-144 might result in enhancements in reverse cholesterol transport and oxysterol metabolism in patients with cardiovascular disease. arthrofactin 212-221 microRNA 144 Homo sapiens 138-145