PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31834435-1 2020 PURPOSE: This study aimed to develop a population pharmacokinetic (PPK) model to investigate the impact of GSTA1, GSTP1, and GSTM1 genotypes on busulfan pharmacokinetic (PK) variability in Chinese adult patients. Busulfan 144-152 glutathione S-transferase alpha 1 Homo sapiens 107-112 31834435-7 2020 The PK of intravenous busulfan was described by one-compartment model with first-order elimination with estimated clearance (CL) of 14.2 L/h and volume of distribution of 64.1 L. Inclusion of GSTA1 genotype as a covariate accounted for 1.1% of the inter-individual variability of busulfan CL (from 17.8% in the basic model to 16.7% in the final model). Busulfan 22-30 glutathione S-transferase alpha 1 Homo sapiens 192-197 31834435-10 2020 CONCLUSIONS: Although the GSTA1 genotype-based PPK model of intravenous busulfan was successfully developed and externally validated, the GSTA1 genotype was not considered to be clinically relevant to busulfan CL. Busulfan 72-80 glutathione S-transferase alpha 1 Homo sapiens 26-31