PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31814565-0 2019 [Downregulation of miR-129-5p alleviates alcohol-induced barrier dysfunction of Caco-2 human intestinal epithelial cells]. Ethanol 41-48 microRNA 1295a Homo sapiens 19-29 31814565-1 2019 Objective To investigate the effect of miR-129-5p on alcohol-induced intestinal epithelial permeability. Ethanol 53-60 microRNA 1295a Homo sapiens 39-49 31814565-6 2019 Alcohol treatment increased miR-129-5p expression in the differentiated Caco-2 cells. Ethanol 0-7 microRNA 1295a Homo sapiens 28-38 31814565-7 2019 Compared with the control group, TER and the protein levels of occludin and ZO-1 decreased in the alcohol group. Ethanol 98-105 occludin Homo sapiens 63-71 31814565-7 2019 Compared with the control group, TER and the protein levels of occludin and ZO-1 decreased in the alcohol group. Ethanol 98-105 tight junction protein 1 Homo sapiens 76-80 31814565-8 2019 Compared with the alcohol group, TER and the protein levels of occludin and ZO-1 were enhanced in the alcohol combined with miR-129-5p group; however, these changes were not altered in the alcohol combined with miR-129-5p inhibitor control group. Ethanol 18-25 occludin Homo sapiens 63-71 31814565-8 2019 Compared with the alcohol group, TER and the protein levels of occludin and ZO-1 were enhanced in the alcohol combined with miR-129-5p group; however, these changes were not altered in the alcohol combined with miR-129-5p inhibitor control group. Ethanol 18-25 tight junction protein 1 Homo sapiens 76-80 31814565-8 2019 Compared with the alcohol group, TER and the protein levels of occludin and ZO-1 were enhanced in the alcohol combined with miR-129-5p group; however, these changes were not altered in the alcohol combined with miR-129-5p inhibitor control group. Ethanol 102-109 occludin Homo sapiens 63-71 31814565-8 2019 Compared with the alcohol group, TER and the protein levels of occludin and ZO-1 were enhanced in the alcohol combined with miR-129-5p group; however, these changes were not altered in the alcohol combined with miR-129-5p inhibitor control group. Ethanol 102-109 tight junction protein 1 Homo sapiens 76-80 31814565-8 2019 Compared with the alcohol group, TER and the protein levels of occludin and ZO-1 were enhanced in the alcohol combined with miR-129-5p group; however, these changes were not altered in the alcohol combined with miR-129-5p inhibitor control group. Ethanol 102-109 occludin Homo sapiens 63-71 31814565-8 2019 Compared with the alcohol group, TER and the protein levels of occludin and ZO-1 were enhanced in the alcohol combined with miR-129-5p group; however, these changes were not altered in the alcohol combined with miR-129-5p inhibitor control group. Ethanol 102-109 tight junction protein 1 Homo sapiens 76-80 31814565-9 2019 Conclusion The miR-129-5p expression is elevated in sigmoid colon biopsies and alcohol-induced differentiated Caco-2 cells from patients with alcoholic liver disease. Ethanol 79-86 microRNA 1295a Homo sapiens 15-25 31814565-10 2019 Inhibition of miR-129-5p can suppress alcohol-induced intestinal epithelial permeability. Ethanol 38-45 microRNA 1295a Homo sapiens 14-24