PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31685558-0 2019 Antitumor activity of the poly(ADP-ribose) polymerase inhibitor rucaparib as monotherapy in patients with platinum-sensitive, relapsed, BRCA-mutated, high-grade ovarian cancer, and an update on safety. rucaparib 64-73 BRCA1 DNA repair associated Homo sapiens 136-140 31685558-1 2019 OBJECTIVE: To report results from an integrated efficacy and safety analysis supporting the European Commission"s approval of the poly(ADP-ribose) polymerase inhibitor rucaparib as monotherapy treatment for relapsed, platinum-sensitive, BRCA-mutated ovarian cancer. rucaparib 168-177 BRCA1 DNA repair associated Homo sapiens 237-241 31685558-9 2019 CONCLUSIONS: In patients with platinum-sensitive, BRCA-mutated ovarian cancer, rucaparib demonstrated antitumor activity and is the first and currently the only poly(ADP-ribose) polymerase inhibitor approved by the European Commission as treatment for this population. rucaparib 79-88 BRCA1 DNA repair associated Homo sapiens 50-54