PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31350260-3 2019 Here, we show that FMRP binds the mRNA of the R-type voltage-gated calcium channel Cav2.3 in mouse brain synaptoneurosomes and represses Cav2.3 translation under basal conditions. Calcium 67-74 calcium channel, voltage-dependent, R type, alpha 1E subunit Mus musculus 83-89 31350260-7 2019 Loss of regulated Cav2.3 expression could underlie the neuronal hyperactivity and aberrant calcium spiking in FMRP KO mice and contribute to FXS, potentially serving as a novel target for future therapeutic strategies.SIGNIFICANCE STATEMENT Patients with fragile X syndrome (FXS) exhibit signs of neuronal and circuit hyperexcitability, including anxiety and hyperactive behavior, attention deficit disorder, and seizures. Calcium 91-98 calcium channel, voltage-dependent, R type, alpha 1E subunit Mus musculus 18-24