PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31337282-6	2019	In this study, we examined the effect of VK2809, a liver-specific thyroid hormone receptor beta agonist, on hepatic steatosis, autophagy, and mitochondrial biogenesis in a mouse model of GSD Ia.	MB-07811	41-47	thyroid hormone receptor beta	Mus musculus	66-95	
31337282-7	2019	Methods: G6pc-/--deficient (GSD Ia) mice were treated with VK2809 or vehicle control by daily intraperitoneal injection for four days.	MB-07811	59-65	glucose-6-phosphatase, catalytic	Mus musculus	9-13	
31337282-11	2019	VK2809 stimulated hepatic autophagic flux as evidenced by increased microtubule-associated protein light chain 3-II (LC3B-II), decreased p62 protein levels, activation of AMP-activated protein kinase (AMPK), inhibition of the mammalian target of rapamycin (mTOR) signaling, enhancement of protein levels of ATG5-ATG12, and increased lysosomal protein expression.	MB-07811	0-6	microtubule associated protein 1 light chain 3 beta	Homo sapiens	117-121	
31337282-11	2019	VK2809 stimulated hepatic autophagic flux as evidenced by increased microtubule-associated protein light chain 3-II (LC3B-II), decreased p62 protein levels, activation of AMP-activated protein kinase (AMPK), inhibition of the mammalian target of rapamycin (mTOR) signaling, enhancement of protein levels of ATG5-ATG12, and increased lysosomal protein expression.	MB-07811	0-6	nucleoporin 62	Homo sapiens	137-140	
31337282-11	2019	VK2809 stimulated hepatic autophagic flux as evidenced by increased microtubule-associated protein light chain 3-II (LC3B-II), decreased p62 protein levels, activation of AMP-activated protein kinase (AMPK), inhibition of the mammalian target of rapamycin (mTOR) signaling, enhancement of protein levels of ATG5-ATG12, and increased lysosomal protein expression.	MB-07811	0-6	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	171-199	
31337282-11	2019	VK2809 stimulated hepatic autophagic flux as evidenced by increased microtubule-associated protein light chain 3-II (LC3B-II), decreased p62 protein levels, activation of AMP-activated protein kinase (AMPK), inhibition of the mammalian target of rapamycin (mTOR) signaling, enhancement of protein levels of ATG5-ATG12, and increased lysosomal protein expression.	MB-07811	0-6	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	201-205	
31337282-11	2019	VK2809 stimulated hepatic autophagic flux as evidenced by increased microtubule-associated protein light chain 3-II (LC3B-II), decreased p62 protein levels, activation of AMP-activated protein kinase (AMPK), inhibition of the mammalian target of rapamycin (mTOR) signaling, enhancement of protein levels of ATG5-ATG12, and increased lysosomal protein expression.	MB-07811	0-6	mechanistic target of rapamycin kinase	Homo sapiens	226-255	
31337282-11	2019	VK2809 stimulated hepatic autophagic flux as evidenced by increased microtubule-associated protein light chain 3-II (LC3B-II), decreased p62 protein levels, activation of AMP-activated protein kinase (AMPK), inhibition of the mammalian target of rapamycin (mTOR) signaling, enhancement of protein levels of ATG5-ATG12, and increased lysosomal protein expression.	MB-07811	0-6	mechanistic target of rapamycin kinase	Homo sapiens	257-261	
31337282-11	2019	VK2809 stimulated hepatic autophagic flux as evidenced by increased microtubule-associated protein light chain 3-II (LC3B-II), decreased p62 protein levels, activation of AMP-activated protein kinase (AMPK), inhibition of the mammalian target of rapamycin (mTOR) signaling, enhancement of protein levels of ATG5-ATG12, and increased lysosomal protein expression.	MB-07811	0-6	autophagy related 5	Homo sapiens	307-311	
31337282-11	2019	VK2809 stimulated hepatic autophagic flux as evidenced by increased microtubule-associated protein light chain 3-II (LC3B-II), decreased p62 protein levels, activation of AMP-activated protein kinase (AMPK), inhibition of the mammalian target of rapamycin (mTOR) signaling, enhancement of protein levels of ATG5-ATG12, and increased lysosomal protein expression.	MB-07811	0-6	autophagy related 12	Homo sapiens	312-317	
31337282-12	2019	VK2809 also increased the expression of carnitine palmitoyltransferase 1a (CPT1alpha) and fibroblast growth factor 21 (FGF21), as well as mitochondrial biogenesis to promote mitochondrial beta-oxidation.	Carnitine	40-49	carnitine palmitoyltransferase 1a, liver	Mus musculus	75-84