PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31120617-0	2019	RasGRP1 is a target for VEGF to induce angiogenesis and involved in the endothelial-protective effects of metformin under high glucose in HUVECs.	Metformin	106-115	vascular endothelial growth factor A	Homo sapiens	24-28	
31120617-4	2019	Furthermore, we investigate whether RasGRP1-dependent VEGF signaling was downregulated under high glucose conditions mimicking diabetes and required for the endothelial protective action of metformin in human umbilical vein endothelial cells (HUVECs).	Metformin	190-199	vascular endothelial growth factor A	Homo sapiens	54-58	
31120617-8	2019	The expression of VEGF, RasGRP1, and AKT phosphorylation was downregulated in HUVECs exposed to high glucose compared with normal glucose, whereas metformin upregulated the RasGRP1-dependent VEGF signaling and ameliorates the impaired angiogenesis caused by high glucose.	Metformin	147-156	vascular endothelial growth factor A	Homo sapiens	191-195