PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30928643-0	2019	Upregulation of tripeptidyl-peptidase 1 by 3-hydroxy-(2,2)-dimethyl butyrate, a brain endogenous ligand of PPARalpha: Implications for late-infantile Batten disease therapy.	3-hydroxy-2,2-dimethylbutyrate	43-76	peroxisome proliferator activated receptor alpha	Mus musculus	107-116	
30928643-5	2019	Moreover, by using primary astrocytes from wild type, PPARalpha-/- and PPARbeta-/- mice, we demonstrated that HDMB specifically required PPARalpha for inducing TPP1 expression.	3-hydroxy-2,2-dimethylbutyrate	110-114	peroxisome proliferator activated receptor alpha	Mus musculus	54-63	
30928643-5	2019	Moreover, by using primary astrocytes from wild type, PPARalpha-/- and PPARbeta-/- mice, we demonstrated that HDMB specifically required PPARalpha for inducing TPP1 expression.	3-hydroxy-2,2-dimethylbutyrate	110-114	peroxisome proliferator activated receptor alpha	Mus musculus	71-79	
30928643-5	2019	Moreover, by using primary astrocytes from wild type, PPARalpha-/- and PPARbeta-/- mice, we demonstrated that HDMB specifically required PPARalpha for inducing TPP1 expression.	3-hydroxy-2,2-dimethylbutyrate	110-114	peroxisome proliferator activated receptor alpha	Mus musculus	137-146	
30928643-6	2019	Finally, oral administration of HDMB to Cln2 heterozygous (Cln2+/-) mice led to a marked upregulation of TPP1 expression in the motor cortex and striatum in a PPARalpha-dependent fashion.	3-hydroxy-2,2-dimethylbutyrate	32-36	peroxisome proliferator activated receptor alpha	Mus musculus	159-168	
30928643-7	2019	Our study suggests that HDMB, a brain endogenous ligand of PPARalpha, might have therapeutic importance for LINCL treatment.	3-hydroxy-2,2-dimethylbutyrate	24-28	peroxisome proliferator activated receptor alpha	Mus musculus	59-68