PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30733293-5 2019 The cannabinoid Delta9-tetrahydrocannabinol (THC) disrupts HER2-CB2R complexes by selectively binding to CB2R, which leads to (i) the inactivation of HER2 through disruption of HER2-HER2 homodimers, and (ii) the subsequent degradation of HER2 by the proteasome via the E3 ligase c-CBL. Dronabinol 16-43 Cbl proto-oncogene Homo sapiens 279-284 30733293-5 2019 The cannabinoid Delta9-tetrahydrocannabinol (THC) disrupts HER2-CB2R complexes by selectively binding to CB2R, which leads to (i) the inactivation of HER2 through disruption of HER2-HER2 homodimers, and (ii) the subsequent degradation of HER2 by the proteasome via the E3 ligase c-CBL. Dronabinol 45-48 Cbl proto-oncogene Homo sapiens 279-284