PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30684529-0	2019	Hinokitiol suppresses growth of B16 melanoma by activating ERK/MKP3/proteosome pathway to downregulate survivin expression.	beta-thujaplicin	0-10	mitogen-activated protein kinase 1	Homo sapiens	59-62	
30684529-0	2019	Hinokitiol suppresses growth of B16 melanoma by activating ERK/MKP3/proteosome pathway to downregulate survivin expression.	beta-thujaplicin	0-10	dual specificity phosphatase 6	Homo sapiens	63-67	
30684529-8	2019	Hinokitiol rapidly induced ERK phosphorylation followed by a sustained dephosphorylation, which accompanied with an increase in expression of tumor suppressor MKP-3 (mitogen-activated protein kinase phosphatase-3).	beta-thujaplicin	0-10	mitogen-activated protein kinase 1	Homo sapiens	27-30	
30684529-8	2019	Hinokitiol rapidly induced ERK phosphorylation followed by a sustained dephosphorylation, which accompanied with an increase in expression of tumor suppressor MKP-3 (mitogen-activated protein kinase phosphatase-3).	beta-thujaplicin	0-10	dual specificity phosphatase 6	Homo sapiens	159-164	
30684529-8	2019	Hinokitiol rapidly induced ERK phosphorylation followed by a sustained dephosphorylation, which accompanied with an increase in expression of tumor suppressor MKP-3 (mitogen-activated protein kinase phosphatase-3).	beta-thujaplicin	0-10	dual specificity phosphatase 6	Homo sapiens	166-212	
30684529-9	2019	Inhibition of hinokitiol-induced ERK activation by MEK inhibitor U0126 completely blocked expression of MKP-3.	beta-thujaplicin	14-24	mitogen-activated protein kinase 1	Homo sapiens	33-36	
30684529-9	2019	Inhibition of hinokitiol-induced ERK activation by MEK inhibitor U0126 completely blocked expression of MKP-3.	beta-thujaplicin	14-24	mitogen-activated protein kinase kinase 7	Homo sapiens	51-54	
30684529-9	2019	Inhibition of hinokitiol-induced ERK activation by MEK inhibitor U0126 completely blocked expression of MKP-3.	beta-thujaplicin	14-24	dual specificity phosphatase 6	Homo sapiens	104-109	
30684529-10	2019	More importantly, inhibition of MKP-3 activity by NSC 95397 significantly inhibited hinokitiol-induced ERK dephosphorylation, ubiquitination and downregulation of survivin.	beta-thujaplicin	84-94	dual specificity phosphatase 6	Homo sapiens	32-37	
30684529-10	2019	More importantly, inhibition of MKP-3 activity by NSC 95397 significantly inhibited hinokitiol-induced ERK dephosphorylation, ubiquitination and downregulation of survivin.	beta-thujaplicin	84-94	mitogen-activated protein kinase 1	Homo sapiens	103-106	
30684529-11	2019	These results suggested that hinokitiol inhibited growth of B16-F10 melanoma through downregulation of survivin by activating ERK/MKP-3/proteosome pathway.	beta-thujaplicin	29-39	mitogen-activated protein kinase 1	Homo sapiens	126-129	
30684529-11	2019	These results suggested that hinokitiol inhibited growth of B16-F10 melanoma through downregulation of survivin by activating ERK/MKP-3/proteosome pathway.	beta-thujaplicin	29-39	dual specificity phosphatase 6	Homo sapiens	130-135