PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30683630-0 2019 Efficacy and Safety of Lorlatinib in Korean Non-Small-Cell Lung Cancer Patients With ALK or ROS1 Rearrangement Whose Disease Failed to Respond to a Previous Tyrosine Kinase Inhibitor. lorlatinib 23-33 ROS proto-oncogene 1, receptor tyrosine kinase Homo sapiens 92-96 30683630-2 2019 Lorlatinib, a novel third-generation TKI, produced remarkable results from the first-in-man phase 1 trial: an overall response rate of 46% and 50% for previously treated ALK- and ROS1-positive patients, respectively. lorlatinib 0-10 ROS proto-oncogene 1, receptor tyrosine kinase Homo sapiens 179-183 30683630-14 2019 CONCLUSION: This study is the first to report that lorlatinib is an important novel therapeutic option for Asian patients who have advanced NSCLC harboring ALK/ROS1 mutations whose disease progressed during treatment with first- and second-generation TKIs. lorlatinib 51-61 ROS proto-oncogene 1, receptor tyrosine kinase Homo sapiens 160-164