PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30633870-9 2019 SARM has been shown to deplete NAD+ by possessing intrinsic NADase activity in the TIR domain of the protein. NAD 31-35 sterile alpha and TIR motif containing 1 Homo sapiens 0-4 30633870-11 2019 It is thought that this activity of SARM is normally switched off by the axo-protective activities of NMNAT2 which maintain low levels of the NAD+ precursor NMN. NAD 142-146 sterile alpha and TIR motif containing 1 Homo sapiens 36-40