PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30610588-2 2019 Thus, we hypothesized that the addition of metformin to everolimus and exemestane, could lead to better outcomes in overweight and obese patients with metastatic, hormone receptor-positive, HER2-negative breast cancer. Metformin 43-52 erb-b2 receptor tyrosine kinase 2 Homo sapiens 190-194 30610588-3 2019 We conducted a phase II trial to evaluate the efficacy and safety of the combination of metformin, everolimus and exemestane in overweight and obese postmenopausal women with metastatic, hormone receptor-positive, HER2-negative breast cancer. Metformin 88-97 erb-b2 receptor tyrosine kinase 2 Homo sapiens 214-218 30610588-11 2019 Conclusion The combination of metformin, everolimus and exemestane was safe and had moderate clinical benefit in overweight and obese with patients metastatic, hormone receptor-positive, HER2-negative breast cancer. Metformin 30-39 erb-b2 receptor tyrosine kinase 2 Homo sapiens 187-191